The Journal of Experimental Medicine
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Published online
doi:10.1084/jem.20080066
The Journal of Experimental Medicine, Vol. 205, No. 4, 747-750
The Rockefeller University Press, 0022-1007 $30.00
© Williams et al.
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COMMENTARY

 The role of CTCF in regulating nuclear organization

Adam Williams and Richard A. Flavell

A.W and R.A.F. are at the Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520

CORRESPONDENCE R.A.F.: richard.flavell{at}yale.edu


ABSTRACT
The spatial organization of the genome is thought to play an important part in the coordination of gene regulation. New techniques have been used to identify specific long-range interactions between distal DNA sequences, revealing an ever-increasing complexity to nuclear organization. CCCTC-binding factor (CTCF) is a versatile zinc finger protein with diverse regulatory functions. New data now help define how CTCF mediates both long-range intrachromosomal and interchromosomal interactions, and highlight CTCF as an important factor in determining the three-dimensional structure of the genome.


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