Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 680K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jolly, C. J. Articles by Manis, J. P. Search for Related Content PubMed PubMed Citation Articles by Jolly, C. J. Articles by Manis, J. P. Related Collections Related Article Social Bookmarking                      What's this?

C.J. Jolly is at Centenary Institute, The University of Sydney, Sydney NSW 2006, Australia
A.J.L. Cook is at UMR 218 Centre National de la Recherche Scientifique/Institut Curie, 75248 Paris, France
J.P. Manis is at Joint Program in Transfusion Medicine and Department of Laboratory Medicine, Children's Hospital Boston, and Department of Pathology, Harvard Medical School, Boston, MA 02115

CORRESPONDENCE J.P.M.: manis{at}enders.tch.harvard.edu

ABSTRACT
Immunoglobulin (Ig) class switch recombination (CSR) involves the breakage and subsequent repair of two DNA sequences, known as switch (S) regions, which flank IgH constant region exons. The resolution of CSR-associated breaks is thought to require the nonhomologous end-joining (NHEJ) DNA repair pathway, but the role of the NHEJ factor DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in this process has been unclear. A new study, in which broken IgH-containing chromosomes in switching B cells were visualized directly, clearly demonstrated that DNA-PKcs and, unexpectedly, the nuclease Artemis are involved in the resolution of switch breaks.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

• Roa, S., Avdievich, E., Peled, J. U., MacCarthy, T., Werling, U., Kuang, F. L., Kan, R., Zhao, C., Bergman, A., Cohen, P. E., Edelmann, W., Scharff, M. D. (2008). Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proc. Natl. Acad. Sci. USA 105: 16248-16253 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS