The Journal of Experimental Medicine
FluoroSpot from Mabtech
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online December 15, 2008
doi:10.1084/jem.20082622
The Journal of Experimental Medicine, Vol. 205, No. 13, 2953-2957
The Rockefeller University Press, 0022-1007 $30.00
© 2008 Bougnères et al.
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 513K)
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bougnères, P.
Right arrow Articles by Valleron, A.-J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bougnères, P.
Right arrow Articles by Valleron, A.-J.
Related Collections
Right arrowRelated Article
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

COMMENTARY

 Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

Pierre Bougnères and Alain-Jacques Valleron

P.B. is at Department of Pediatric Endocrinology and U561 INSERM, Saint Vincent de Paul Hospital, Paris V René Descartes University, 75014 Paris, France
A.-J.V. is at Unité de Santé Publique and U707 INSERM, Saint Antoine Hospital, Paris VI Pierre et Marie Curie University, 75012 Paris, France

CORRESPONDENCE P.B.: bougneres{at}paris5.inserm.fr


ABSTRACT
A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and β cell destruction are not yet known, but the identification of a metabolic phenotype linked to susceptibility to type I diabetes may help pave the way to a new era of investigation of T1D causality.

© 2008 Bougnères and Valleron This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
Matej Oresic, Satu Simell, Marko Sysi-Aho, Kirsti Näntö-Salonen, Tuulikki Seppänen-Laakso, Vilhelmiina Parikka, Mikko Katajamaa, Anne Hekkala, Ismo Mattila, Päivi Keskinen, Laxman Yetukuri, Arja Reinikainen, Jyrki Lähde, Tapani Suortti, Jari Hakalax, Tuula Simell, Heikki Hyöty, Riitta Veijola, Jorma Ilonen, Riitta Lahesmaa, Mikael Knip, and Olli Simell
J. Exp. Med. 2008 205: 2975-2984. [Abstract] [Full Text] [PDF]





  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS