The Journal of Experimental Medicine
Avanti Polar Lipids, Inc.
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Published online
doi:10.1084/jem.20082622
The Journal of Experimental Medicine, Vol. 205, No. 13, 2953-2957
The Rockefeller University Press, 0022-1007 $30.00
© Bougnères et al.
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COMMENTARY

 Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

Pierre Bougnères and Alain-Jacques Valleron

P.B. is at Department of Pediatric Endocrinology and U561 INSERM, Saint Vincent de Paul Hospital, Paris V René Descartes University, 75014 Paris, France
A.-J.V. is at Unité de Santé Publique and U707 INSERM, Saint Antoine Hospital, Paris VI Pierre et Marie Curie University, 75012 Paris, France

CORRESPONDENCE P.B.: bougneres{at}paris5.inserm.fr


ABSTRACT
A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and β cell destruction are not yet known, but the identification of a metabolic phenotype linked to susceptibility to type I diabetes may help pave the way to a new era of investigation of T1D causality.

© 2008 Bougnères and Valleron This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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