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¹ Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304
² Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305
³ Inflammation Department, Millennium Pharmaceuticals, Cambridge, MA 02139
⁴ Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093
⁵ Department of Anatomy, Chonbuk National University Medical School, Jeonju, Republic of Korea
⁶ Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305

CORRESPONDENCE Stephen J. Galli: sgalli{at}stanford.edu OR Brian A. Zabel: bazabel{at}alum.mit.edu

Mast cells contribute importantly to both protective and pathological IgE-dependent immune responses. We show that the mast cell–expressed orphan serpentine receptor mCCRL2 is not required for expression of IgE-mediated mast cell–dependent passive cutaneous anaphylaxis but can enhance the tissue swelling and leukocyte infiltrates associated with such reactions in mice. We further identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. In contrast to other "silent" or professional chemokine interreceptors, chemerin binding does not trigger ligand internalization. Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1.

B. Zabel and S. Nakae contributed equally to this paper.

S. Nakae's present address is National Research Institute for Child Health and Development, Tokyo, Japan.

J.-Y. Kim and J. Pan's present address is Bayer Healthcare Pharmaceuticals, Inc., Berkeley, CA.

T. Ohyama's present address is Daiichi Sankyo Co., Ltd., Tokyo, Japan.

C. Alt's present address is SRI International, Menlo Park, CA.

H. Suto's present address is Atopy Research Center, Juntendo University, Tokyo, Japan.

© 2008 Zabel et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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• Yoshimura, T., Oppenheim, J. J. (2008). Chemerin reveals its chimeric nature. JEM 205: 2187-2190 [Abstract] [Full Text]  

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