The Journal of Experimental Medicine
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Published online September 22, 2008
doi:10.1084/jem.20081736
The Journal of Experimental Medicine, Vol. 205, No. 10, 2187-2190
The Rockefeller University Press, 0022-1007 $30.00
© 2008 Yoshimura et al.
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COMMENTARY

 Chemerin reveals its chimeric nature

Teizo Yoshimura and Joost J. Oppenheim

T.Y. and J.J.O. are at Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702

CORRESPONDENCE T.Y.: yoshimut{at}mail.nih.gov


ABSTRACT
Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.

© 2008 Yoshimura and Oppenheim This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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