The Journal of Experimental Medicine
Avanti Polar Lipids, Inc.
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Published online
doi:10.1084/jem.2048fta
The Journal of Experimental Medicine, Vol. 204, No. 8, 1735-
The Rockefeller University Press, 0022-1007 $30.00
© Bashyam
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FROM THE ARCHIVE

 Receptor editing: How B cells stay tolerant

Hema Bashyam, JEM News Editor

hbashyam{at}rockefeller.edu


ABSTRACT
In 1993, David Nemazee and Martin Weigert independently showed that autoreactive B cells could proofread, alter, and reexpress modified receptors to become nonautoreactive. This process, called "receptor editing," has since gained prominence as the main mechanism of B cell tolerance.


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