Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) PPT slides of all figures Supplemental Material Index Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Codarri, L. Articles by Pantaleo, G. Search for Related Content PubMed PubMed Citation Articles by Codarri, L. Articles by Pantaleo, G. Related Collections Related Article Social Bookmarking                      What's this?

Expansion and tissue infiltration of an allospecific CD4⁺CD25⁺CD45RO⁺IL-7R^high cell population in solid organ transplant recipients

¹ Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Department of Medicine, ² Transplantation Center, and ³ Institute of Pathology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland
⁴ Service of Nephrology and Transplantation, Hôpitaux Universitaires de Genève, University of Geneva, 1211 Geneva 14, Switzerland

CORRESPONDENCE Giuseppe Pantaleo: giuseppe.pantaleo{at}chuv.ch OR Manuel Pascual: manuel.pascual{at}chuv.ch

It has been recently shown (Seddiki, N., B. Santner-Nanan, J. Martinson, J. Zaunders, S. Sasson, A. Landay, M. Solomon, W. Selby, S.I. Alexander, R. Nanan, et al. 2006. J. Exp. Med. 203:1693–1700.) that the expression of interleukin (IL) 7 receptor (R) discriminates between two distinct CD4 T cell populations, both characterized by the expression of CD25, i.e. CD4 regulatory T (T reg) cells and activated CD4 T cells. T reg cells express low levels of IL-7R, whereas activated CD4 T cells are characterized by the expression of IL-7R^high. We have investigated the distribution of these two CD4 T cell populations in 36 subjects after liver and kidney transplantation and in 45 healthy subjects. According to a previous study (Demirkiran, A., A. Kok, J. Kwekkeboom, H.J. Metselaar, H.W. Tilanus, and L.J. van der Laan. 2005. Transplant. Proc. 37:1194–1196.), we observed that the T reg CD25⁺CD45RO⁺IL-7R^low cell population was reduced in transplant recipients (P < 0.00001). Interestingly, the CD4⁺CD25⁺CD45RO⁺IL-7R^high cell population was significantly increased in stable transplant recipients compared with healthy subjects (P < 0.00001), and the expansion of this cell population was even greater in patients with documented humoral chronic rejection compared with stable transplant recipients (P < 0.0001). The expanded CD4⁺CD25⁺CD45RO⁺IL-7R^high cell population contained allospecific CD4 T cells and secreted effector cytokines such as tumor necrosis factor and interferon , thus potentially contributing to the mechanisms of chronic rejection. More importantly, CD4⁺IL-7R⁺and CD25⁺IL-7R⁺ cells were part of the T cell population infiltrating the allograft of patients with a documented diagnosis of chronic humoral rejection. These results indicate that the CD4⁺CD25⁺IL-7R⁺ cell population may represent a valuable, sensitive, and specific marker to monitor allospecific CD4 T cell responses both in blood and in tissues after organ transplantation.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Related Article

Keeping score of antigraft T cells

Hema Bashyam
J. Exp. Med. 2007 204: 1505. [Full Text] [PDF]

This article has been cited by other articles:

• Koenen, H. J. P. M., Smeets, R. L., Vink, P. M., van Rijssen, E., Boots, A. M. H., Joosten, I. (2008). Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 112: 2340-2352 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS