The Journal of Experimental Medicine
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Published online
doi:10.1084/jem.20062305
The Journal of Experimental Medicine, Vol. 204, No. 7, 1525-1531
The Rockefeller University Press, 0022-1007 $30.00
© Skokos et al.
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BRIEF DEFINITIVE REPORT

 CD8– DCs induce IL-12–independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS

Dimitris Skokos1 and Michel C. Nussenzweig1,2

1 Laboratory of Molecular Immunology and 2 Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021

CORRESPONDENCE Michel C. Nussenzweig: nussen{at}mail.rockefeller.edu

Toll-like receptor (TLR) ligation is believed to skew T cell responses toward T helper (Th)1 differentiation by inducing interleukin (IL)-12 secretion by CD8+ dendritic cells (DCs). However, TLR-dependent Th1 responses occur in the absence of IL-12. To determine how DCs induce Th1 differentiation in the absence of IL-12, we examined the response of IL-12–deficient DCs to bacterial lipopolysaccharide (LPS). We find that LPS activates MyD88-dependent Delta 4 Notch-like ligand expression by CD8– DCs, and that these cells direct Th1 differentiation by an IL-12–independent and Notch-dependent mechanism in vitro and in vivo. Thus, activation of the two DC subsets by TLR4 leads to Th1 responses by two distinct MyD88-dependent pathways.


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