The Journal of Experimental Medicine
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Published online
doi:10.1084/jem.20061675
The Journal of Experimental Medicine, Vol. 204, No. 7, 1509-1517
The Rockefeller University Press, 0022-1007 $30.00
© Angkasekwinai et al.
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BRIEF DEFINITIVE REPORT

 Interleukin 25 promotes the initiation of proallergic type 2 responses

Pornpimon Angkasekwinai1,2, Heon Park3, Yui-Hsi Wang1, Yi-Hong Wang1, Seon Hee Chang1, David B. Corry4, Yong-Jun Liu1, Zhou Zhu5, and Chen Dong1

1 University of Texas MD Anderson Cancer Center, Houston, TX 77030
2 Thammasat University, Pathum-thani 12121, Thailand
3 University of Washington, Seattle, WA 98195
4 Baylor College of Medicine, Houston, TX 77030
5 Johns Hopkins University, Baltimore, MD 21224

CORRESPONDENCE Chen Dong: cdong{at}mdanderson.org

The molecular mechanisms underlying the initiation of innate and adaptive proallergic type 2 responses are not understood. Interleukin (IL) 25, a member of the IL-17 cytokine family, was recently reported (Owyang, A.M., C. Zaph, E.H. Wilson, K.J. Guild, T. McClanahan, H.R. Miller, D.J. Cua, M. Goldschmidt, C.A. Hunter, R.A. Kastelein, and D. Artis. 2006. J. Exp. Med. 203:843–849; Fallon, P.G., S.J. Ballantyne, N.E. Mangan, J.L. Barlow, A. Dasvarma, D.R. Hewett, A. McIlgorm, H.E. Jolin, and A.N. McKenzie. 2006. J. Exp. Med. 203:1105–1116) to be important in Th2 cell–mediated immunity to parasitic infection. However, the cellular source and targets of IL-25 are not well understood. We show that mouse IL-25 is expressed by lung epithelial cells as a result of innate immune responses to allergens. Transgenic overexpression of IL-25 by these cells leads to mucus production and airway infiltration of macrophages and eosinophils, whereas blockade of IL-25 conversely reduces the airway inflammation and Th2 cytokine production in an allergen-induced asthma model. In addition, IL-25, with a receptor more highly expressed in Th2 than other effector T cells, promotes Th2 cell differentiation in an IL-4– and signal transducer and activator of transcription 6–dependent manner. During early T cell activation, IL-25 potentiates expression of the nuclear factor of activated T cells c1 and JunB transcription factors, which possibly results in increased levels of initial IL-4 production, up-regulation of GATA-3 expression, and enhanced Th2 cell differentiation. Thus, IL-25 is a critical factor regulating the initiation of innate and adaptive proallergic responses.


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