The Journal of Experimental Medicine
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Published online February 20, 2007
doi:10.1084/jem.2042fta
The Journal of Experimental Medicine, Vol. 204, No. 2, 237-
The Rockefeller University Press, 0022-1007 $30.00
© 2007 Bashyam
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FROM THE ARCHIVE

 Th1/Th2 cross-regulation and the discovery of IL-10

Hema Bashyam, JEM News Editor

hbashyam{at}rockefeller.edu


ABSTRACT
In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory. Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells.


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