Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 3881K) PPT slides of all figures Supplemental Material Index Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cho, H.-J. Articles by Yoon, Y.-s. Search for Related Content PubMed PubMed Citation Articles by Cho, H.-J. Articles by Yoon, Y.-s. Social Bookmarking                            What's this?

Division of Cardiovascular Research, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135

CORRESPONDENCE Young-sup Yoon: young.yoon{at}tufts.edu

Noncellular differentiation effects have emerged as important mechanisms mediating therapeutic effects of stem or progenitor cell transplantation. Here, we investigated the expression patterns and sources of humoral factors and their regional and systemic biological effects after bone marrow (BM)-derived endothelial progenitor cell (EPC) transplantation into ischemic myocardium. Although most of the transplanted EPCs disappeared within a week, up-regulation of multiple humoral factors was sustained for longer than two weeks, which correlated well with the recovery of cardiac function. To determine the source of the humoral factors, we injected human EPCs into immunodeficient mice. Whereas the expression of human EPC (donor)-derived cytokines rapidly decreased to a nondetectable level within a week, up-regulation of mouse (recipient)-derived cytokines, including factors that could mobilize BM cells, was sustained. Histologically, we observed higher capillary density, a higher proliferation of myocardial cells, a lower cardiomyocyte apoptosis, and reduced infarct size. Furthermore, after EPC transplantation, BM-derived stem or progenitor cells were increased in the peripheral circulation and incorporated into the site of neovascularization and myocardial repair. These data indicate that myocardial EPC transplantation induces humoral effects, which are sustained by host tissues and play a crucial role in repairing myocardial injury.

H.-J. Cho and N. Lee contributed equally to this work.

H.-J. Cho's present address is Dept. of Internal Medicine, Seoul National University Hospital, Yongon-Dong, Seoul 110-744, South Korea.

N. Lee's present address is Div. of Cardiology, Kangnam Sacred Heart Hospital/Hallym University School of Medicine, Seoul 150-950, South Korea.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Seeger, F. H., Rasper, T., Koyanagi, M., Fox, H., Zeiher, A. M., Dimmeler, S. (2009). CXCR4 Expression Determines Functional Activity of Bone Marrow-Derived Mononuclear Cells for Therapeutic Neovascularization in Acute Ischemia. Arterioscler. Thromb. Vasc. Bio. 29: 1802-1809 [Abstract] [Full Text]  
• Gianella, A., Guerrini, U., Tilenni, M., Sironi, L., Milano, G., Nobili, E., Vaga, S., Capogrossi, M. C., Tremoli, E., Pesce, M. (2009). Magnetic resonance imaging of human endothelial progenitors reveals opposite effects on vascular and muscle regeneration into ischaemic tissues. Cardiovasc Res 0: cvp325v2-cvp325 [Abstract] [Full Text]  
• Chang, S.-A, Kim, Y.-J., Lee, H.-W., Kim, D.-H., Kim, H.-K., Chang, H.-J., Sohn, D.-W., Oh, B.-H., Park, Y.-B. (2009). Effect of Rosuvastatin on Cardiac Remodeling, Function, and Progression to Heart Failure in Hypertensive Heart With Established Left Ventricular Hypertrophy. Hypertension 54: 591-597 [Abstract] [Full Text]  
• Shabbir, A., Zisa, D., Suzuki, G., Lee, T. (2009). Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen. Am. J. Physiol. Heart Circ. Physiol. 296: H1888-H1897 [Abstract] [Full Text]  
• Gaetani, R., Ledda, M., Barile, L., Chimenti, I., De Carlo, F., Forte, E., Ionta, V., Giuliani, L., D'Emilia, E., Frati, G., Miraldi, F., Pozzi, D., Messina, E., Grimaldi, S., Giacomello, A., Lisi, A. (2009). Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields. Cardiovasc Res 82: 411-420 [Abstract] [Full Text]  
• Cesselli, D., Beltrami, A. P., Rigo, S., Bergamin, N., D'Aurizio, F., Verardo, R., Piazza, S., Klaric, E., Fanin, R., Toffoletto, B., Marzinotto, S., Mariuzzi, L., Finato, N., Pandolfi, M., Leri, A., Schneider, C., Beltrami, C. A., Anversa, P. (2009). Multipotent Progenitor Cells Are Present in Human Peripheral Blood. Circ. Res. 104: 1225-1234 [Abstract] [Full Text]  
• Barcelos, L. S., Duplaa, C., Krankel, N., Graiani, G., Invernici, G., Katare, R., Siragusa, M., Meloni, M., Campesi, I., Monica, M., Simm, A., Campagnolo, P., Mangialardi, G., Stevanato, L., Alessandri, G., Emanueli, C., Madeddu, P. (2009). Human CD133+ Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling. Circ. Res. 104: 1095-1102 [Abstract] [Full Text]  
• Suuronen, E. J., Zhang, P., Kuraitis, D., Cao, X., Melhuish, A., McKee, D., Li, F., Mesana, T. G., Veinot, J. P., Ruel, M. (2009). An acellular matrix-bound ligand enhances the mobilization, recruitment and therapeutic effects of circulating progenitor cells in a hindlimb ischemia model. FASEB J. 23: 1447-1458 [Abstract] [Full Text]  
• Zhang, Y., Ingram, D. A., Murphy, M. P., Saadatzadeh, M. R., Mead, L. E., Prater, D. N., Rehman, J. (2009). Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells. Am. J. Physiol. Heart Circ. Physiol. 296: H1675-H1682 [Abstract] [Full Text]  
• Bonder, C. S., Sun, W. Y., Matthews, T., Cassano, C., Li, X., Ramshaw, H. S., Pitson, S. M., Lopez, A. F., Coates, P. T., Proia, R. L., Vadas, M. A., Gamble, J. R. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood 113: 2108-2117 [Abstract] [Full Text]  
• Jeong, J.-O., Kim, M.-O., Kim, H., Lee, M.-Y., Kim, S.-W., Ii, M., Lee, J.-u., Lee, J., Choi, Y. J., Cho, H.-J., Lee, N., Silver, M., Wecker, A., Kim, D.-W., Yoon, Y.-s. (2009). Dual Angiogenic and Neurotrophic Effects of Bone Marrow-Derived Endothelial Progenitor Cells on Diabetic Neuropathy. Circulation 119: 699-708 [Abstract] [Full Text]  
• Korf-Klingebiel, M., Kempf, T., Sauer, T., Brinkmann, E., Fischer, P., Meyer, G. P., Ganser, A., Drexler, H., Wollert, K. C. (2008). Bone marrow cells are a rich source of growth factors and cytokines: implications for cell therapy trials after myocardial infarction. Eur Heart J 29: 2851-2858 [Abstract] [Full Text]  
• Ziebart, T., Yoon, C.-H., Trepels, T., Wietelmann, A., Braun, T., Kiessling, F., Stein, S., Grez, M., Ihling, C., Muhly-Reinholz, M., Carmona, G., Urbich, C., Zeiher, A. M., Dimmeler, S. (2008). Sustained Persistence of Transplanted Proangiogenic Cells Contributes to Neovascularization and Cardiac Function After Ischemia. Circ. Res. 103: 1327-1334 [Abstract] [Full Text]  
• Ruel, M., Stewart, A. F.R., Suuronen, E. J. (2008). From Genes to Regenerative Medicine: Approaches in Development. Circ. Res. 103: 1050-1052 [Full Text]  
• Zhang, Y., Thorn, S., DaSilva, J. N., Lamoureux, M., deKemp, R. A., Beanlands, R. S., Ruel, M., Suuronen, E. J. (2008). Collagen-Based Matrices Improve the Delivery of Transplanted Circulating Progenitor Cells: Development and Demonstration by Ex Vivo Radionuclide Cell Labeling and In Vivo Tracking With Positron-Emission Tomography. Circ Cardiovasc Imaging 1: 197-204 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS