The Journal of Experimental Medicine
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Published online October 8, 2007
doi:10.1084/jem.20070991
The Journal of Experimental Medicine, Vol. 204, No. 11, 2561-2568
The Rockefeller University Press, 0022-1007 $30.00
© 2007 Blasius et al.
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BRIEF DEFINITIVE REPORT

 Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells

Amanda L. Blasius, Winfried Barchet, Marina Cella, and Marco Colonna

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110

CORRESPONDENCE Marco Colonna: mcolonna{at}pathology.wustl.edu

Lymphoid organs contain a B220+CD11c+NK1.1+ cell population that was recently characterized as a novel dendritic cell (DC) subset that functionally overlaps with natural killer (NK) cells and plasmacytoid DCs (PDCs). Using Siglec-H and NK1.1 markers, we unambiguously dissected B220+CD11c+ cells and found that PDCs are the only professional interferon (IFN)-{alpha}–producing cells within this heterogeneous population. In contrast, B220+CD11c+NK1.1+ cells are a discrete NK cell subset capable of producing higher levels of IFN-{gamma} than conventional NK cells. Unlike DCs, only a minute fraction of B220+CD11c+NK1.1+ cells in the spleen expressed major histocompatibility complex class II ex vivo or after stimulation with CpG. Consistent with being a NK cell subset, B220+CD11c+NK1.1+ cells depended primarily on interleukin 15 and common cytokine receptor {gamma} chain signaling for their development. In terms of function, expression of distinctive cell surface receptors, and location in lymphoid organs, NK1.1+B220+CD11c+ appear to be the murine equivalent of human CD56bright NK cells.

W. Barchet's present address is Institute for Clinical Biochemistry and Pharmacology, University Hospital, University of Bonn, 53105 Bonn, Germany.


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