The Journal of Experimental Medicine
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Published online
doi:10.1084/jem.2041fta
The Journal of Experimental Medicine, Vol. 204, No. 1, 3-
The Rockefeller University Press, 0022-1007 $30.00
© Bashyam
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FROM THE ARCHIVE

 IFN{gamma}: Issuing macrophages a license to kill

Hema Bashyam, JEM News Editor

hbashyam{at}rockefeller.edu


ABSTRACT
T cells tell macrophages when to start making the toxic soup of lysosomal enzymes, reactive oxygen species, and nitric oxide that destroys intracellular pathogens. In 1983, Carl Nathan proved that this start signal comes in the form of the secreted cytokine IFN{gamma}.


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