Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 740K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Khader, S. A. Articles by Cooper, A. M. Search for Related Content PubMed PubMed Citation Articles by Khader, S. A. Articles by Cooper, A. M. Related Collections Related Article Social Bookmarking                            What's this?

¹ Trudeau Institute, Inc., Saranac Lake, NY 12983
² Genentech Inc., South San Francisco, CA 94080

CORRESPONDENCE Andrea M. Cooper: acooper{at}trudeauinstitute.org

Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40. This defect compromises the ability of IL-12p40–deficient DCs to activate naive T cells in vivo; however, DCs that express IL-12p40 alone can activate naive T cells. Treatment of IL-12p40–deficient DCs with IL-12p40 homodimer (IL-12(p40)₂) restores Mtb-induced DC migration and the ability of IL-12p40–deficient DCs to activate naive T cells. These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs.

S. Partida-Sanchez's present address is Columbus Children's Research Institute, Columbus, OH 43205.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

Related Article

Dendritic cell paralysis

Heather L. Van Epps
J. Exp. Med. 2006 203: 1621. [Full Text] [PDF]

This article has been cited by other articles:

• Lin, Y.-L., Liang, Y.-C., Tseng, Y.-S., Huang, H.-Y., Chou, S.-Y., Hseu, R.-S., Huang, C.-T., Chiang, B.-L. (2009). An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-{kappa}B and MAPK pathways. J. Leukoc. Biol. 86: 877-889 [Abstract] [Full Text]  
• Day, J., Friedman, A., Schlesinger, L. S. (2009). Modeling the immune rheostat of macrophages in the lung in response to infection. Proc. Natl. Acad. Sci. USA 106: 11246-11251 [Abstract] [Full Text]  
• Rothfuchs, A. G., Egen, J. G., Feng, C. G., Antonelli, L. R. V., Bafica, A., Winter, N., Locksley, R. M., Sher, A. (2009). In Situ IL-12/23p40 Production during Mycobacterial Infection Is Sustained by CD11bhigh Dendritic Cells Localized in Tissue Sites Distinct from Those Harboring Bacilli. J. Immunol. 182: 6915-6925 [Abstract] [Full Text]  
• Perona-Wright, G., Jenkins, S. J., O'Connor, R. A., Zienkiewicz, D., McSorley, H. J., Maizels, R. M., Anderton, S. M., MacDonald, A. S. (2009). A Pivotal Role for CD40-Mediated IL-6 Production by Dendritic Cells during IL-17 Induction In Vivo. J. Immunol. 182: 2808-2815 [Abstract] [Full Text]  
• Schulz, S. M., Kohler, G., Schutze, N., Knauer, J., Straubinger, R. K., Chackerian, A. A., Witte, E., Wolk, K., Sabat, R., Iwakura, Y., Holscher, C., Muller, U., Kastelein, R. A., Alber, G. (2008). Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17. J. Immunol. 181: 7891-7901 [Abstract] [Full Text]  
• Robinson, R. T., Khader, S. A., Locksley, R. M., Lien, E., Smiley, S. T., Cooper, A. M. (2008). Yersinia pestis Evades TLR4-dependent Induction of IL-12(p40)2 by Dendritic Cells and Subsequent Cell Migration. J. Immunol. 181: 5560-5567 [Abstract] [Full Text]  
• McCormick, S., Santosuosso, M., Small, C.-L., Shaler, C. R., Zhang, X., Jeyanathan, M., Mu, J., Takenaka, S., Ngai, P., Gauldie, J., Wan, Y., Xing, Z. (2008). Mucosally Delivered Dendritic Cells Activate T Cells Independently of IL-12 and Endogenous APCs. J. Immunol. 181: 2356-2367 [Abstract] [Full Text]  
• Reiley, W. W., Calayag, M. D., Wittmer, S. T., Huntington, J. L., Pearl, J. E., Fountain, J. J., Martino, C. A., Roberts, A. D., Cooper, A. M., Winslow, G. M., Woodland, D. L. (2008). ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes. Proc. Natl. Acad. Sci. USA 105: 10961-10966 [Abstract] [Full Text]  
• Kim, D.-J., Youn, J.-I., Seo, S.-H., Jin, H.-T., Sung, Y.-C. (2008). Differential Regulation of Antigen-Specific CD8+ T Cell Responses by IL-12p40 in a Dose-Dependent Manner. J. Immunol. 180: 7167-7174 [Abstract] [Full Text]  
• Schaefer, M., Reiling, N., Fessler, C., Stephani, J., Taniuchi, I., Hatam, F., Yildirim, A. O., Fehrenbach, H., Walter, K., Ruland, J., Wagner, H., Ehlers, S., Sparwasser, T. (2008). Decreased Pathology and Prolonged Survival of Human DC-SIGN Transgenic Mice during Mycobacterial Infection. J. Immunol. 180: 6836-6845 [Abstract] [Full Text]  
• Wagner, C. S., Walther-Jallow, L., Buentke, E., Ljunggren, H.-G., Achour, A., Chambers, B. J. (2008). Human cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells. J. Leukoc. Biol. 83: 56-63 [Abstract] [Full Text]  
• Rothfuchs, A. G., Bafica, A., Feng, C. G., Egen, J. G., Williams, D. L., Brown, G. D., Sher, A. (2007). Dectin-1 Interaction with Mycobacterium tuberculosis Leads to Enhanced IL-12p40 Production by Splenic Dendritic Cells. J. Immunol. 179: 3463-3471 [Abstract] [Full Text]  
• Del Vecchio, M., Bajetta, E., Canova, S., Lotze, M. T., Wesa, A., Parmiani, G., Anichini, A. (2007). Interleukin-12: Biological Properties and Clinical Application. Clin. Cancer Res. 13: 4677-4685 [Abstract] [Full Text]  
• Cleret, A., Quesnel-Hellmann, A., Vallon-Eberhard, A., Verrier, B., Jung, S., Vidal, D., Mathieu, J., Tournier, J.-N. (2007). Lung Dendritic Cells Rapidly Mediate Anthrax Spore Entry through the Pulmonary Route. J. Immunol. 178: 7994-8001 [Abstract] [Full Text]  
• Shamshiev, A. T., Ampenberger, F., Ernst, B., Rohrer, L., Marsland, B. J., Kopf, M. (2007). Dyslipidemia inhibits Toll-like receptor-induced activation of CD8{alpha}-negative dendritic cells and protective Th1 type immunity. JEM 204: 441-452 [Abstract] [Full Text]  
• Thurnher, M. (2007). Lipids in dendritic cell biology: messengers, effectors, and antigens. J. Leukoc. Biol. 81: 154-160 [Abstract] [Full Text]  
• Kullberg, M. C., Jankovic, D., Feng, C. G., Hue, S., Gorelick, P. L., McKenzie, B. S., Cua, D. J., Powrie, F., Cheever, A. W., Maloy, K. J., Sher, A. (2006). IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. JEM 203: 2485-2494 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS