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ARTICLE |
enhancer controls the generation of CD4–CD8– 
ßTCR-expressing T cells that can give rise to different lineages of ß T cells
CORRESPONDENCE Harald von Boehmer: harald_von_boehmer{at}dfci.harvard.edu
It is well established that the pre–T cell receptor for antigen (TCR) is responsible for efficient expansion and differentiation of thymocytes with productive TCRß rearrangements. However, Ptcra- as well as Tcra-targeting experiments have suggested that the early expression of Tcra in CD4–CD8– cells can partially rescue the development of
ß CD4+CD8+ cells in Ptcra-deficient mice. In this study, we show that the TCR E
but not E enhancer function is required for the cell surface expression of ßTCR on immature CD4–CD8– T cell precursors, which play a crucial role in promoting ß T cell development in the absence of pre-TCR. Thus, ßTCR expression by CD4–CD8– thymocytes not only represents a transgenic artifact but occurs under physiological conditions.
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