The Journal of Experimental Medicine
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Published online 8 May 2006 doi:10.1084/jem.20060849
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 5, 1143-1145
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COMMENTARY

 Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene

Steven E. Artandi

S.E.A. is at Department of Medicine, Division of Hematology, and Cancer Biology Program, Stanford School of Medicine, Stanford, CA 94305.

CORRESPONDENCE S.E.A.: sartandi{at}stanford.edu


ABSTRACT
Telomerase, the enzyme that elongates our telomeres, is crucial for cancer development based on extensive analyses of human cells, human cancers, and mouse models. New data now suggest that a viral telomerase RNA gene encoded by Marek's disease virus (MDV), an oncogenic herpesvirus of chickens, promotes tumor formation. These findings highlight the importance of telomerase in cancer and raise new questions regarding the mechanisms by which the telomerase RNA component supports tumorigenesis.


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