The Journal of Experimental Medicine
Avanti Polar Lipids, Inc.
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online 27 March 2006 doi:10.1084/jem.20052367
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 4, 953-960
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 1196K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cumberbatch, M.
Right arrow Articles by Griffiths, C. E.M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cumberbatch, M.
Right arrow Articles by Griffiths, C. E.M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

ARTICLE

 Impaired Langerhans cell migration in psoriasis

Marie Cumberbatch1, Minal Singh2, Rebecca J. Dearman1, Helen S. Young2, Ian Kimber1, and Christopher E.M. Griffiths2

1 Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK
2 The Dermatology Centre, University of Manchester, Salford, Manchester, M6 8HD, England, UK

CORRESPONDENCE Christopher E.M. Griffiths: Christopher.griffiths{at}manchester.ac.uk

We have examined whether psoriasis is associated with systemic effects on epidermal Langerhans cell (LC) function and, specifically, the migration of LCs from the skin. Compared with normal skin, the frequency and morphology of epidermal LCs in uninvolved skin from patients with psoriasis was normal. However, mobilization of these cells in response to stimuli that normally induce migration (chemical allergen, tumor necrosis factor {alpha} [TNF-{alpha}], and interleukin-1ß [IL-1ß]) was largely absent, despite the fact that treatment with TNF-{alpha} and IL-1ß was associated with comparable inflammatory reactions in patients and controls. The failure of LC migration from uninvolved skin was not attributable to altered expression of receptors for IL-1ß or TNF-{alpha} that are required for mobilization, nor was there an association with induced cutaneous cytokine expression. Although a role for altered dynamics of LC migration/turnover has not been formally excluded, these data reveal a very consistent decrement of LC function in psoriasis that may play a decisive role in disease pathogenesis.

Abbreviations used: LC, Langerhans cell; DPC, diphenylcyclopropenone; IL-1Ra, IL-1R antagonist; PDC, plasmacytoid DC.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS