Published online 10 April 2006 doi:10.1084/jem.20060219
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 4, 817-820
New battlefields for costimulation
Natalia Martin-Orozco and
Chen Dong
N.M-O. and C.D. are at Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030.
CORRESPONDENCE N.M-O.: nmorozco{at}mdanderson.org OR C.D.: cdong{at}mdanderson.org
Abstract
Costimulation regulates the activation of naive T cells as they first encounter antigens in the secondary lymphoid organs. But recently characterized costimulatory molecules of the B7 family appear to have roles beyond initial T cell activation. New evidence shows that negative costimulators expressed by tumors and normal tissues afford local protection from T cell–mediated attack.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Related Articles
-
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
- Ilona Kryczek, Linhua Zou, Paulo Rodriguez, Gefeng Zhu, Shuang Wei, Peter Mottram, Michael Brumlik, Pui Cheng, Tyler Curiel, Leann Myers, Andrew Lackner, Xavier Alvarez, Augusto Ochoa, Lieping Chen, and Weiping Zou
J. Exp. Med. 2006 203: 871-881.
[Abstract]
[Full Text]
[PDF]
-
Tissue expression of PD-L1 mediates peripheral T cell tolerance
- Mary E. Keir, Spencer C. Liang, Indira Guleria, Yvette E. Latchman, Andi Qipo, Lee A. Albacker, Maria Koulmanda, Gordon J. Freeman, Mohamed H. Sayegh, and Arlene H. Sharpe
J. Exp. Med. 2006 203: 883-895.
[Abstract]
[Full Text]
[PDF]
This article has been cited by other articles:
-
Brenk, M., Scheler, M., Koch, S., Neumann, J., Takikawa, O., Hacker, G., Bieber, T., von Bubnoff, D.
(2009). Tryptophan Deprivation Induces Inhibitory Receptors ILT3 and ILT4 on Dendritic Cells Favoring the Induction of Human CD4+CD25+ Foxp3+ T Regulatory Cells. J. Immunol.
183: 145-154
[Abstract]
[Full Text]
-
Lafon, M., Megret, F., Meuth, S. G., Simon, O., Velandia Romero, M. L., Lafage, M., Chen, L., Alexopoulou, L., Flavell, R. A., Prehaud, C., Wiendl, H.
(2008). Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis. J. Immunol.
180: 7506-7515
[Abstract]
[Full Text]
-
Amatschek, S., Kriehuber, E., Bauer, W., Reininger, B., Meraner, P., Wolpl, A., Schweifer, N., Haslinger, C., Stingl, G., Maurer, D.
(2007). Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environment. Blood
109: 4777-4785
[Abstract]
[Full Text]
