Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 1376K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Heinecke, J. W. Search for Related Content PubMed PubMed Citation Articles by Heinecke, J. W. Related Collections Related Article Social Bookmarking                            What's this?

J.W.H. is at Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195.

CORRESPONDENCE J.W.H.: heinecke{at}u.washington.edu.

Abstract
Oxidation of low-density lipoprotein (LDL) is thought to contribute to atherosclerosis and cardiovascular disease. Consistent with this idea, the antioxidant drug probucol reduces the risk of restenosis, a form of cardiovascular disease, in humans. However, a new study now suggests that the protective effect of probucol depends not on its ability to inhibit lipid oxidation, but on its ability to induce the stress-induced antiinflammatory enzyme heme oxygenase (HO)-1. This might explain why other antioxidants, such as vitamin E, fail to prevent cardiovascular disease in humans.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Facebook

Reddit

Technorati

Twitter

This article has been cited by other articles:

• Abraham, N. G., Kappas, A. (2008). Pharmacological and Clinical Aspects of Heme Oxygenase. Pharmacol. Rev. 60: 79-127 [Abstract] [Full Text]  
• Sachse, A., Wolf, G. (2007). Angiotensin II Induced Reactive Oxygen Species and the Kidney. J. Am. Soc. Nephrol. 18: 2439-2446 [Abstract] [Full Text]  
• Weihrauch, D., Xu, H., Shi, Y., Wang, J., Brien, J., Jones, D. W., Kaul, S., Komorowski, R. A., Csuka, M. E., Oldham, K. T., Pritchard, K. A. (2007). Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice. Am. J. Physiol. Heart Circ. Physiol. 293: H1432-H1441 [Abstract] [Full Text]  
• Sarov-Blat, L., Kiss, R. S., Haidar, B., Kavaslar, N., Jaye, M., Bertiaux, M., Steplewski, K., Hurle, M. R., Sprecher, D., McPherson, R., Marcel, Y. L. (2007). Predominance of a Proinflammatory Phenotype in Monocyte-Derived Macrophages From Subjects With Low Plasma HDL-Cholesterol. Arterioscler. Thromb. Vasc. Bio. 27: 1115-1122 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS