The Journal of Experimental Medicine
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Published online 10 April 2006 doi:10.1084/jem.20060522
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 4, 809-812
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COMMENTARY

 Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!

Cristina M. Tato, Arian Laurence, and John J. O'Shea

C.M.T., A.L., and J.J.O. are at Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.

CORRESPONDENCE C.M.T: tatoc{at}mail.nih.gov


Abstract
In the dark ages of T cell biology, we considered two fates for differentiated CD4+ T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17–related cytokine IL-25 is essential for Th2 responses in two infectious disease models.


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