Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 2454K) PPT slides of all figures Supplemental Material Index Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tadokoro, C. E. Articles by Dustin, M. L. Search for Related Content PubMed PubMed Citation Articles by Tadokoro, C. E. Articles by Dustin, M. L. Related Collections Related Article Social Bookmarking                      What's this?

¹ Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, and ² Department of Pathology, New York University School of Medicine, New York, NY 10016

CORRESPONDENCE Juan J. Lafaille: lafaille{at}saturn.med.nyu.edu OR Michael L. Dustin: dustin{at}saturn.med.nyu.edu

Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

• Van, Y.-H., Lee, W.-H., Ortiz, S., Lee, M.-H., Qin, H.-J., Liu, C.-P. (2009). All-trans Retinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-{gamma}-Producing T-cells Without Affecting Th17 Cells. Diabetes 58: 146-155 [Abstract] [Full Text]  
• Abe, J., Ueha, S., Suzuki, J., Tokano, Y., Matsushima, K., Ishikawa, S. (2008). Increased Foxp3+ CD4+ Regulatory T Cells with Intact Suppressive Activity but Altered Cellular Localization in Murine Lupus. Am. J. Pathol. 173: 1682-1692 [Abstract] [Full Text]  
• Dolganiuc, A., Szabo, G. (2008). T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't. J. Leukoc. Biol. 84: 614-622 [Abstract] [Full Text]  
• Onishi, Y., Fehervari, Z., Yamaguchi, T., Sakaguchi, S. (2008). Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc. Natl. Acad. Sci. USA 105: 10113-10118 [Abstract] [Full Text]  
• Winstead, C. J., Fraser, J. M., Khoruts, A. (2008). Regulatory CD4+CD25+Foxp3+ T Cells Selectively Inhibit the Spontaneous Form of Lymphopenia-Induced Proliferation of Naive T Cells. J. Immunol. 180: 7305-7317 [Abstract] [Full Text]  
• Carvalho-Gaspar, M., Jones, N. D., Luo, S., Martin, L., Brook, M. O., Wood, K. J. (2008). Location and Time-Dependent Control of Rejection by Regulatory T Cells Culminates in a Failure to Generate Memory T Cells. J. Immunol. 180: 6640-6648 [Abstract] [Full Text]  
• Li, Y., Ma, L., Yin, D., Shen, J., Chong, A. S. (2008). Long-Term Control of Alloreactive B Cell Responses by the Suppression of T Cell Help. J. Immunol. 180: 6077-6084 [Abstract] [Full Text]  
• Piconese, S., Valzasina, B., Colombo, M. P. (2008). OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. JEM 205: 825-839 [Abstract] [Full Text]  
• Esquerre, M., Tauzin, B., Guiraud, M., Muller, S., Saoudi, A., Valitutti, S. (2008). Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-{beta}-dependent mechanism. Proc. Natl. Acad. Sci. USA 105: 2550-2555 [Abstract] [Full Text]  
• Hanig, J., Lutz, M. B. (2008). Suppression of Mature Dendritic Cell Function by Regulatory T Cells In Vivo Is Abrogated by CD40 Licensing. J. Immunol. 180: 1405-1413 [Abstract] [Full Text]  
• Chai, J.-G., Coe, D., Chen, D., Simpson, E., Dyson, J., Scott, D. (2008). In Vitro Expansion Improves In Vivo Regulation by CD4+CD25+ Regulatory T Cells. J. Immunol. 180: 858-869 [Abstract] [Full Text]  
• Chappert, P., Leboeuf, M., Rameau, P., Stockholm, D., Liblau, R., Danos, O., Davoust, J. M., Gross, D.-A. (2008). Antigen-Driven Interactions with Dendritic Cells and Expansion of Foxp3+ Regulatory T Cells Occur in the Absence of Inflammatory Signals. J. Immunol. 180: 327-334 [Abstract] [Full Text]  
• Tiemessen, M. M., Jagger, A. L., Evans, H. G., van Herwijnen, M. J. C., John, S., Taams, L. S. (2007). CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc. Natl. Acad. Sci. USA 104: 19446-19451 [Abstract] [Full Text]  
• Cuda, C. M., Wan, S., Sobel, E. S., Croker, B. P., Morel, L. (2007). Murine Lupus Susceptibility Locus Sle1a Controls Regulatory T Cell Number and Function through Multiple Mechanisms. J. Immunol. 179: 7439-7447 [Abstract] [Full Text]  
• DiPaolo, R. J., Brinster, C., Davidson, T. S., Andersson, J., Glass, D., Shevach, E. M. (2007). Autoantigen-Specific TGFbeta-Induced Foxp3+ Regulatory T Cells Prevent Autoimmunity by Inhibiting Dendritic Cells from Activating Autoreactive T Cells. J. Immunol. 179: 4685-4693 [Abstract] [Full Text]  
• John, R., Nelson, P. J. (2007). Dendritic Cells in the Kidney. J. Am. Soc. Nephrol. 18: 2628-2635 [Abstract] [Full Text]  
• Derks, R. A., Jankowska-Gan, E., Xu, Q., Burlingham, W. J. (2007). Dendritic Cell Type Determines the Mechanism of Bystander Suppression by Adaptive T Regulatory Cells Specific for the Minor Antigen HA-1. J. Immunol. 179: 3443-3451 [Abstract] [Full Text]  
• Gaudreau, S., Guindi, C., Menard, M., Besin, G., Dupuis, G., Amrani, A. (2007). Granulocyte-Macrophage Colony-Stimulating Factor Prevents Diabetes Development in NOD Mice by Inducing Tolerogenic Dendritic Cells that Sustain the Suppressive Function of CD4+CD25+ Regulatory T Cells. J. Immunol. 179: 3638-3647 [Abstract] [Full Text]  
• Kang, S. G., Lim, H. W., Andrisani, O. M., Broxmeyer, H. E., Kim, C. H. (2007). Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells. J. Immunol. 179: 3724-3733 [Abstract] [Full Text]  
• Sakaguchi, S., Powrie, F. (2007). Emerging Challenges in Regulatory T Cell Function and Biology. Science 317: 627-629 [Abstract] [Full Text]  
• Yuan, Q., Bromley, S. K., Means, T. K., Jones, K. J., Hayashi, F., Bhan, A. K., Luster, A. D. (2007). CCR4-dependent regulatory T cell function in inflammatory bowel disease. JEM 204: 1327-1334 [Abstract] [Full Text]  
• Sather, B. D., Treuting, P., Perdue, N., Miazgowicz, M., Fontenot, J. D., Rudensky, A. Y., Campbell, D. J. (2007). Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease. JEM 204: 1335-1347 [Abstract] [Full Text]  
• Schneider, M. A., Meingassner, J. G., Lipp, M., Moore, H. D., Rot, A. (2007). CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells. JEM 204: 735-745 [Abstract] [Full Text]  
• Nguyen, V. H., Zeiser, R., daSilva, D. L., Chang, D. S., Beilhack, A., Contag, C. H., Negrin, R. S. (2007). In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation. Blood 109: 2649-2656 [Abstract] [Full Text]  
• Haribhai, D., Lin, W., Relland, L. M., Truong, N., Williams, C. B., Chatila, T. A. (2007). Regulatory T Cells Dynamically Control the Primary Immune Response to Foreign Antigen. J. Immunol. 178: 2961-2972 [Abstract] [Full Text]  
• Boissonnas, A., Fetler, L., Zeelenberg, I. S., Hugues, S., Amigorena, S. (2007). In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor. JEM 204: 345-356 [Abstract] [Full Text]  
• Kobayashi, N., Hiraoka, N., Yamagami, W., Ojima, H., Kanai, Y., Kosuge, T., Nakajima, A., Hirohashi, S. (2007). FOXP3+ Regulatory T Cells Affect the Development and Progression of Hepatocarcinogenesis. Clin. Cancer Res. 13: 902-911 [Abstract] [Full Text]  
• Cabbage, S. E., Huseby, E. S., Sather, B. D., Brabb, T., Liggitt, D., Goverman, J. (2007). Regulatory T Cells Maintain Long-Term Tolerance to Myelin Basic Protein by Inducing a Novel, Dynamic State of T Cell Tolerance. J. Immunol. 178: 887-896 [Abstract] [Full Text]  
• Wan, S., Xia, C., Morel, L. (2007). IL-6 Produced by Dendritic Cells from Lupus-Prone Mice Inhibits CD4+CD25+ T Cell Regulatory Functions. J. Immunol. 178: 271-279 [Abstract] [Full Text]  
• Sathish, J. G., Dolton, G., LeRoy, F. G., Matthews, R. J. (2007). Loss of Src Homology Region 2 Domain-Containing Protein Tyrosine Phosphatase-1 Increases CD8+ T Cell-APC Conjugate Formation and Is Associated with Enhanced In Vivo CTL Function. J. Immunol. 178: 330-337 [Abstract] [Full Text]  
• Strickland, D. H., Stumbles, P. A., Zosky, G. R., Subrata, L. S., Thomas, J. A., Turner, D. J., Sly, P. D., Holt, P. G. (2006). Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells. JEM 203: 2649-2660 [Abstract] [Full Text]  
• Sukiennicki, T. L., Fowell, D. J. (2006). Distinct Molecular Program Imposed on CD4+ T Cell Targets by CD4+CD25+ Regulatory T Cells. J. Immunol. 177: 6952-6961 [Abstract] [Full Text]  
• Schneider, H., Downey, J., Smith, A., Zinselmeyer, B. H., Rush, C., Brewer, J. M., Wei, B., Hogg, N., Garside, P., Rudd, C. E. (2006). Reversal of the TCR Stop Signal by CTLA-4. Science 313: 1972-1975 [Abstract] [Full Text]  
• Tadokoro, C. E., Shakhar, G., Shen, S., Ding, Y., Lino, A. C., Maraver, A., Lafaille, J. J., Dustin, M. L. (2006). Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. JCB 172: i17-i17 [Full Text]  
• Rudensky, A. Y., Campbell, D. J. (2006). In vivo sites and cellular mechanisms of T reg cell-mediated suppression. JEM 203: 489-492 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS