The Journal of Experimental Medicine
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Published online 13 March 2006 doi:10.1084/jem.20060216
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 3, 501-503
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COMMENTARY

 Immune responses and HIV: a little order from the chaos

David H. O'Connor and Dennis R. Burton

D.O. is at University of Wisconsin-Madison, Department of Pathology and Laboratory Medicine, Madison, WI 53711.
D.B. is at Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037.

CORRESPONDENCE D.O.: doconnor{at}primate.wisc.edu OR D.B.: burton{at}scripps.edu


Abstract
HIV is evolution gone mad and bad. The virus infects a person and rapidly diversifies to become a huge swarm of viruses, each equipped differently to resist the onslaught of diverse T cells and antibodies. We can't expect to predict details of the struggle between virus and immunity, right? Wrong—maybe we can make some predictions, say two new landmark studies with potentially huge consequences for AIDS vaccine design.


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J. Exp. Med. 2006 203: 529-539. [Abstract] [Full Text] [PDF]





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