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A.Y.R. is at Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195.
D.J.C. is at Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195 and Benaroya Research Institute, Seattle, WA 98101.

CORRESPONDENCE A.Y.R.: aruden{at}u.washington.edu OR D.J.C.: campbell{at}benaroyaresearch.org

Abstract
Regulatory CD4 T (T reg) cells control immune responses to self-antigens and pathogens. However, where T reg cells act to curtail effector T cells in vivo and what stage of effector T cell activation or differentiation is targeted by T reg cells remain unknown. Furthermore, a requirement for direct effector T cell–T reg cell contact in vivo has not been ascertained. Varying answers to these important questions have been provided by several new studies.

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