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¹ Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854
² Department of Internal Medicine, Sanofi-Aventis, Bridgewater, NJ 08807
³ Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520
⁴ Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232

CORRESPONDENCE Yufang Shi: shiyu{at}umdnj.edu OR Gobardhan Das: dasgo{at}umdnj.edu

Unlike T cells restricted by major histocompatibility complex (MHC) class Ia or class II molecules, T cells restricted by MHC class I–like molecules demonstrate properties of both innate and adaptive immunity and are therefore considered innate-like lymphocytes (ILLs). ILLs are believed to have immunoregulatory functions, but their roles in autoimmunity and defense against infections remain elusive. To study the properties of ILLs, we generated mice expressing only MHC class I–like molecules by crossing CIITA^–/– with K^b–/–D^b–/– mice. Surprisingly, these mice developed a lymphoproliferative syndrome and autoimmunity, most notably inflammatory bowel disease (IBD) and insulitis. The CD8⁺ ILLs in these mice exhibit a constitutively activated phenotype, and depletion of these cells abolished the autoimmune disorders. In addition, adoptive transfer of CD8⁺ ILLs from K^b–/–D^b–/–CIITA^–/– mice to Rag-1^–/–pfn^–/– mice also resulted in IBD and insulitis. These findings provide direct evidence that CD8⁺ ILLs are sufficient to initiate and mediate autoimmune diseases.

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This article has been cited by other articles:

• Jay, D. C., Reed-Loisel, L. M., Jensen, P. E. (2008). Polyclonal MHC Ib-Restricted CD8+ T Cells Undergo Homeostatic Expansion in the Absence of Conventional MHC-Restricted T Cells. J. Immunol. 180: 2805-2814 [Abstract] [Full Text]  

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