The Journal of Experimental Medicine
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Published online 16 October 2006 doi:10.1084/jem.20061754
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 11, 2409-2412
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COMMENTARY

 Giving blood: a new role for CD40 in tumorigenesis

Stephan Bergmann and Pier Paolo Pandolfi

CORRESPONDENCE P.P.P.: p-pandolfi{at}ski.mskcc.org


ABSTRACT
CD40 was initially identified as a receptor expressed by B cells that is crucial for inducing an effective adaptive immune response. CD40 was subsequently shown to be expressed by endothelial cells and to promote angiogenesis. New data now show that in tumor-prone transgenic mice, CD40-mediated neovascularization is essential for early stage tumorigenicity. This suggests, at least in this mouse model, that CD40 has an important role in the angiogenic process that is coupled to carcinogenesis, a finding that could lead to novel therapeutic opportunities.

S.B. and P.P.P. are at the Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.


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