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Published online 23 October 2006 doi:10.1084/jem.20061840
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 11, 2405-2408
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COMMENTARY

 The price of the CD27–CD70 costimulatory axis: you can't have it all

Martijn A. Nolte and René A.W. van Lier

M.A.N.: m.a.nolte{at}amc.uva.nl


ABSTRACT
T cells require costimulatory signals for optimal proliferation, differentiation, and survival and thus to induce protective immune responses. Recent data, however, show that during chronic lymphocyte choriomeningitis virus (LCMV) infection, triggering of the costimulatory receptor CD27 by its ligand CD70 impedes neutralizing antibody production and leads to viral persistence. Thus, while being crucial for the induction of some adaptive effector pathways, costimulation may block the development of others. Pathogens may exploit this Achilles' heal to achieve persistence.

M.A.N. and R.A.W.v.L. are at Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, Netherlands


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