The Journal of Experimental Medicine
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Published online 5 September 2006 doi:10.1084/jem.20060411
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 10, 2305-2314
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ARTICLE

 B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion

David Savitsky1 and Kathryn Calame2

1 Department of Biological Sciences and 2 Departments of Microbiology and Biochemistry & Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032

CORRESPONDENCE Kathryn Calame: KLC1{at}columbia.edu

B-1 B cells produce circulating natural antibodies that provide "innate-like" protection against bacterial and viral pathogens. They also provide adaptive responses to blood and air-borne pathogens. B lymphocyte–induced maturation protein 1 (Blimp-1) is a transcriptional repressor that is required for the formation of B-2–derived antibody-secreting plasma cells. In this study, we used mice lacking Blimp-1 in the B cell lineage to show that Blimp-1 is not necessary for the formation or self-renewal of B-1 B cells but that Blimp-1 is required for normal immunoglobulin (Ig) secretion by B-1 cells. B-1 cells lacking Blimp-1 do not repress Pax5 mRNA and do not induce X-box binding protein 1, and µ secreted mRNA normally, showing that B-1 and B-2 cells both use a common pathway for Ig secretion. Blimp-1–deficient B-1 B cells are also defective in providing early protection against influenza infection.

Abbreviations used: BCR, B cell receptor; Blimp-1, B lymphocyte–induced maturation protein 1; CKO, conditional knockout; µs, secreted µ heavy chain; PerC, peritoneal cavity; XBP-1, X-box binding protein 1.


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