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G5 Dynamiques des Réponses Immunes, INSERM 668, Département d'Immunologie, Institut Pasteur, 75015 Paris, France

CORRESPONDENCE Philippe Bousso: bousso{at}pasteur.fr

The cellular mode of T cell priming in vivo remains to be characterized fully. We investigated the fate of T cell–dendritic cell (DC) interactions in the late phase of T cell activation in the lymph node. In general, CD4 T cells detach from DCs before undergoing cell division. Using a new approach to track the history of antigen (Ag)-recognition events, we demonstrated that activated/divided T cells reengage different DCs in an Ag-specific manner. Two-photon imaging of intact lymph nodes suggested that T cells could establish prolonged interactions with DCs at multiple stages during the activation process. Importantly, signals that are delivered during subsequent DC contacts are integrated by the T cell and promote sustained IL-2R expression and IFN- production. Thus, repeated encounters with Ag-bearing DCs can occur in vivo and modulate CD4 T cell differentiation programs.

S. Celli and Z. Garcia contributed equally to this work.

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