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¹ Department of Pathology and Laboratory Medicine, School of Veterinary Medicine
² Abramson Family Cancer Research Institute, School of Veterinary Medicine
³ Institute for Medicine and Engineering, School of Veterinary Medicine
⁴ Department of Pathobiology, School of Veterinary Medicine
⁵ Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA 19104

CORRESPONDENCE Warren S. Pear: wpear{at}mail.med.upenn.edu

Notch ligands and receptors have been implicated in helper T cell (Th cell) differentiation. Whether Notch signals are involved in differentiation of T helper type 1 (Th1) cells, Th2 cells, or both, however, remains unresolved. To clarify the role of Notch in Th cell differentiation, we generated mice that conditionally inactivate Notch signaling in mature T cells. Mice that lack Notch signaling in CD4⁺ T cells fail to develop a protective Th2 cell response against the gastrointestinal helminth Trichuris muris. In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection. These data demonstrate that Notch signaling is a regulator of type 2 immunity.

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