The Journal of Experimental Medicine
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Published online 8 August 2005 doi:10.1084/jem.20042463
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 202, Number 4, 551-560
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ARTICLE

 IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites

Alexandre Morrot, Julius C.R. Hafalla, Ian A. Cockburn, Luzia H. Carvalho, and Fidel Zavala

Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205

CORRESPONDENCE Fidel Zavala: fzavala{at}jhsph.edu

IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites. Memory CD8+ T cells lacking the IL-4R are unable to establish a stable population residing in nonlymphoid organs, although they develop normally in lymphoid organs. Because memory cells from nonlymphoid organs disappear shortly after immunization, the protective antiparasitic activity of this T cell response also is lost. These results demonstrate that IL-4/IL-4R interactions on CD8+ T cells play a critical role in modulating the development and tissue distribution of memory cells induced by parasite immunization. They also indicate that memory cells residing in nonlymphoid tissues are critical for protective immunity against malaria parasites.

Abbreviations used: IL-4R, IL-4 receptor.

J.C.R. Hafalla's present address is Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010.

L.H. Carvalho's present address is Centro de Pesquisas Rene Rachou, FIOCRUZ, Minas Gerais 30190-002, Brazil.


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