The Journal of Experimental Medicine
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Published 15 August 2005. doi:10.1084/jem.20041503
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 202, Number 4, 541-549
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ARTICLE

 Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin

Jane Yoo2, Miyuki Omori1, Dora Gyarmati1, Baohua Zhou1, Theingi Aye1, Avery Brewer3, Michael R. Comeau3, Daniel J. Campbell1,2, and Steven F. Ziegler1

1 Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101
2 Department of Immunology, University of Washington School of Medicine, Seattle, WA 98101
3 Amgen Corporation, Seattle, WA 98199

CORRESPONDENCE Steven F. Ziegler: sziegler{at}benaroyaresearch.org

The cytokine thymic stromal lymphopoietin (TSLP) has recently been implicated in the pathogenesis of atopic dermatitis (AD) and other allergic diseases in humans. To further characterize its role in this disease process, transgenic mice were generated that express a keratinocyte-specific, tetracycline-inducible TSLP transgene. Skin-specific overexpression of TSLP resulted in an AD-like phenotype, with the development of eczematous lesions containing inflammatory dermal cellular infiltrates, a dramatic increase in Th2 CD4+ T cells expressing cutaneous homing receptors, and elevated serum levels of IgE. These transgenic mice demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin and provide a valuable animal model for future study of this common disease.

Abbreviations used: AD, atopic dermatitis; dox, doxycycline; H&E, hematoxylin and eosin; NLC, normal littermate control; TSLP, thymic stromal lymphopoietin.

J. Yoo and M. Omori contributed equally to this work.


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