The Journal of Experimental Medicine
FluoroSpot from Mabtech
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online 25 July 2005 doi:10.1084/jem.20050308
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 202, Number 3, 437-444
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 1249K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chakravarti, S.
Right arrow Articles by Kuchroo, V. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chakravarti, S.
Right arrow Articles by Kuchroo, V. K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

ARTICLE

 Tim-2 regulates T helper type 2 responses and autoimmunity

Sumone Chakravarti1, Catherine A. Sabatos1, Sheng Xiao1, Zsolt Illes1, Eugene K. Cha1, Raymond A. Sobel2,3, Xin X. Zheng4, Terry B. Strom4, and Vijay K. Kuchroo1

1 Department of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115
2 VA Health Care System, Palo Alto, CA 94304
3 Department of Pathology, Stanford University School of Medicine, Stanford, CA 95305
4 Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215

CORRESPONDENCE Vijay K. Kuchroo: vkuchroo{at}rics.bwh.harvard.edu

Identification of the T cell immunoglobulin mucin-domain containing (Tim) gene family introduced a new family of cell surface molecules that is involved in the regulation of immune responses. We previously demonstrated that Tim-3 is expressed on terminally differentiated T helper (Th)1 cells, and serves to regulate Th1 immune responses. Here, we describe the identification and function of Tim-2, a novel member of the Tim gene family. In contrast with Tim-3, we demonstrate that Tim-2 is expressed preferentially in differentiated Th2 cells. Blockade of the Tim-2/Tim-2 ligand interaction, by administration of soluble Tim-2 fusion protein (Tim-2 immunoglobulin [Ig]), results in T cell hyperproliferation and the production of Th2 cytokines. Administration of Tim-2 Ig during the induction phase reduces the severity of experimental autoimmune encephalomyelitis, a Th1-mediated autoimmune disease model of multiple sclerosis. We propose that Tim-2, an orthologue of human Tim-1, is critical for the regulation of Th2 responses during autoimmune inflammation.

Abbreviations used: EAE, experimental autoimmune encephalomyelitis; HA, hemagglutinin A; HAV, hepatitis A virus; hIgG, human IgG; PLP, proteolipid protein; Tim, T cell immunoglobulin mucin-domain containing.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS