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T.A.M.G. and J.N. are at Div. of Tumor Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

CORRESPONDENCE J.N.: J.NEEFJES{at}NKI.NL

Abstract
Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system, in which the machinery required for peptide loading of MHC class I molecules is introduced directly into the phagosome. Here, we discuss the evidence for and against the ER-phagosome concept as well as other possible mechanisms of cross-presentation.

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