The Journal of Experimental Medicine
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Published online 27 June 2005 doi:10.1084/jem.2021fta
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 202, Number 1, 4-4
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FROM THE ARCHIVE

 Thomas Rivers and the EAE model

Heather L. Van Epps

JEM News Editor


Abstract
In the early 1930s, Thomas Rivers and colleagues provided the first evidence that immune cells can attack the brain. Their simple experiments established what is now the most well-studied model of autoimmunity—the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis.


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