Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 563K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gillard, G. O. Articles by Farr, A. G. Search for Related Content PubMed PubMed Citation Articles by Gillard, G. O. Articles by Farr, A. G. Social Bookmarking                      What's this?

^a G.O.G. is at the Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195.
^b A.G.F. is at the Department of Immunology and Department of Biostructure, University of Washington School of Medicine, Seattle, WA 98195.

CORRESPONDENCE A.G.F.: farr{at}u.washington.edu

Abstract
Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model—whereby TRA expression is regulated by conserved developmental programs active in developing mTECs—may be equally plausible.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

• Yano, M., Kuroda, N., Han, H., Meguro-Horike, M., Nishikawa, Y., Kiyonari, H., Maemura, K., Yanagawa, Y., Obata, K., Takahashi, S., Ikawa, T., Satoh, R., Kawamoto, H., Mouri, Y., Matsumoto, M. (2008). Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. JEM 205: 2827-2838 [Abstract] [Full Text]  
• Dooley, J., Erickson, M., Farr, A. G. (2008). Alterations of the Medullary Epithelial Compartment in the Aire-Deficient Thymus: Implications for Programs of Thymic Epithelial Differentiation. J. Immunol. 181: 5225-5232 [Abstract] [Full Text]  
• Villasenor, J., Besse, W., Benoist, C., Mathis, D. (2008). Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated. Proc. Natl. Acad. Sci. USA 105: 15854-15859 [Abstract] [Full Text]  
• Derbinski, J., Pinto, S., Rosch, S., Hexel, K., Kyewski, B. (2008). Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proc. Natl. Acad. Sci. USA 105: 657-662 [Abstract] [Full Text]  
• Gray, D., Abramson, J., Benoist, C., Mathis, D. (2007). Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. JEM 204: 2521-2528 [Abstract] [Full Text]  
• Gillard, G. O., Dooley, J., Erickson, M., Peltonen, L., Farr, A. G. (2007). Aire-Dependent Alterations in Medullary Thymic Epithelium Indicate a Role for Aire in Thymic Epithelial Differentiation. J. Immunol. 178: 3007-3015 [Abstract] [Full Text]  
• Lomada, D., Liu, B., Coghlan, L., Hu, Y., Richie, E. R. (2007). Thymus Medulla Formation and Central Tolerance Are Restored in IKK{alpha}-/- Mice That Express an IKK{alpha} Transgene in Keratin 5+ Thymic Epithelial Cells. J. Immunol. 178: 829-837 [Abstract] [Full Text]  
• Gillard, G. O., Farr, A. G. (2006). The thymus: a house dividing. Blood 108: 3629-3630 [Full Text]  
• Gillard, G. O., Farr, A. G. (2006). Features of Medullary Thymic Epithelium Implicate Postnatal Development in Maintaining Epithelial Heterogeneity and Tissue-Restricted Antigen Expression. J. Immunol. 176: 5815-5824 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS