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^a H.T.P. is at Scripps-Florida Research Institute, Jupiter, FL 33458.
^b P.W.K. is at Immunobiology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.

CORRESPONDENCE H.T.P.: hpetrie{at}scripps.edu

Abstract
The thymus manufactures new T cells throughout life but contains no self-renewing potential. Instead, replenishment depends on recruitment of bone marrow–derived progenitors that circulate in the blood. Attempts to identify thymic-homing progenitors, and to assess the degree to which they are precommitted to the T cell lineage, have led to complex and sometimes conflicting results. As described here, this probably reflects the existence of multiple distinct types of T cell lineage progenitors as well as differences in individual experimental approaches.

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