The Journal of Experimental Medicine
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Published 18 April 2005. doi:10.1084/jem.20050158
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 8, 1197-1203
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BRIEF DEFINITIVE REPORT

 IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF

Kazu Kikuchi, Anne Y. Lai, Chia-Lin Hsu, and Motonari Kondo

Department of Immunology, Duke University Medical Center, Durham, NC 27710

CORRESPONDENCE Motonari Kondo: motonari.kondo{at}duke.edu

Cytokine receptor signals have been suggested to stimulate cell differentiation during hemato/lymphopoiesis. Such action, however, has not been clearly demonstrated. Here, we show that adult B cell development in IL-7–/– and IL-7R{alpha}2/– mice is arrested at the pre–pro-B cell stage due to insufficient expression of the B cell–specific transcription factor EBF and its target genes, which form a transcription factor network in determining B lineage specification. EBF expression is restored in IL-7–/– pre–pro-B cells upon IL-7 stimulation or in IL-7R{alpha}–/– pre–pro-B cells by activation of STAT5, a major signaling molecule downstream of the IL-7R signaling pathway. Furthermore, enforced EBF expression partially rescues B cell development in IL-7R{alpha}–/– mice. Thus, IL-7 receptor signaling is a participant in the formation of the transcription factor network during B lymphopoiesis by up-regulating EBF, allowing stage transition from the pre–pro-B to further maturational stages.


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