Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 2525K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jelley-Gibbs, D. M. Articles by Swain, S. L. Search for Related Content PubMed PubMed Citation Articles by Jelley-Gibbs, D. M. Articles by Swain, S. L. Related Collections Related Article Social Bookmarking                      What's this?

Trudeau Institute Inc., Saranac Lake, NY 12983

CORRESPONDENCE Dawn M. Jelley-Gibbs: djgibbs{at}trudeauinstitute.org

Chronic infections often result in CD8 T-cell deletion or functional nonresponsiveness. However, to date no definitive studies have attempted to determine the impact of repeated T cell receptor stimulation on CD4 effector T cell generation. We have determined that when antigen presentation is limited to 2 d, optimum in vitro CD4 effector generation is achieved. Alternatively, repeated stimulation results in decreased CD4 effector expansion, decreased cytokine production, and altered migration. Similarly, functionally impaired effectors develop in vivo when antigen-pulsed antigen-presenting cells are replenished every 24 h during a primary immune response. CD4 effectors that are generated with repeated stimulation provide no protection during influenza infection, and have an impaired ability to provide cognate help to B cells. These results suggest that duration of antigen presentation dictates CD4 effector function, and repeated T cell receptor stimulation in vitro and in vivo that exceeds an optimal threshold results in effectors with impaired function.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Related Article

Overstimulated and ineffective

Heather L. Van Epps
J. Exp. Med. 2005 201: 1023. [Full Text] [PDF]

This article has been cited by other articles:

• Colpitts, S. L., Dalton, N. M., Scott, P. (2009). IL-7 Receptor Expression Provides the Potential for Long-Term Survival of Both CD62Lhigh Central Memory T Cells and Th1 Effector Cells during Leishmania major Infection. J. Immunol. 182: 5702-5711 [Abstract] [Full Text]  
• Penitente, R., Nicolo, C., Van den Elzen, P., Di Sante, G., Agrati, C., Aloisi, F., Sercarz, E. E., Ria, F. (2008). Administration of PLP139-151 Primes T Cells Distinct from Those Spontaneously Responsive In Vitro to This Antigen. J. Immunol. 180: 6611-6622 [Abstract] [Full Text]  
• Sarkar, S., Kalia, V., Haining, W. N., Konieczny, B. T., Subramaniam, S., Ahmed, R. (2008). Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. JEM 205: 625-640 [Abstract] [Full Text]  
• Girish, C. K., Smith, T. K., Boermans, H. J., Karrow, N. A. (2008). Effects of Feeding Blends of Grains Naturally Contaminated With Fusarium Mycotoxins on Performance, Hematology, Metabolism, and Immunocompetence of Turkeys. Poult. Sci. 87: 421-432 [Abstract] [Full Text]  
• Lohning, M., Hegazy, A. N., Pinschewer, D. D., Busse, D., Lang, K. S., Hofer, T., Radbruch, A., Zinkernagel, R. M., Hengartner, H. (2008). Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. JEM 205: 53-61 [Abstract] [Full Text]  
• Curtis, J. L., Freeman, C. M., Hogg, J. C. (2007). The Immunopathogenesis of Chronic Obstructive Pulmonary Disease: Insights from Recent Research. Proc Am Thorac Soc 4: 512-521 [Abstract] [Full Text]  
• Jelley-Gibbs, D. M., Dibble, J. P., Brown, D. M., Strutt, T. M., McKinstry, K. K., Swain, S. L. (2007). Persistent Depots of Influenza Antigen Fail To Induce a Cytotoxic CD8 T Cell Response. J. Immunol. 178: 7563-7570 [Abstract] [Full Text]  
• Brown, D. M., Dilzer, A. M., Meents, D. L., Swain, S. L. (2006). CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch.. J. Immunol. 177: 2888-2898 [Abstract] [Full Text]  
• Kedzierska, K., Venturi, V., Field, K., Davenport, M. P., Turner, S. J., Doherty, P. C. (2006). Early establishment of diverse T cell receptor profiles for influenza-specific CD8+CD62Lhi memory T cells. Proc. Natl. Acad. Sci. USA 103: 9184-9189 [Abstract] [Full Text]  
• Yang, C.-P., Sparshott, S. M., Duffy, D., Garside, P., Bell, E. B. (2006). The phenotype and survival of antigen-stimulated transgenic CD4 T cells in vivo: the influence of persisting antigen. Int Immunol 18: 515-523 [Abstract] [Full Text]  
• Ramer, A. E., Vanloubbeeck, Y. F., Jones, D. E. (2006). Antigen-Responsive CD4+ T Cells from C3H Mice Chronically Infected with Leishmania amazonensis Are Impaired in the Transition to an Effector Phenotype. Infect. Immun. 74: 1547-1554 [Abstract] [Full Text]  
• Gondois-Rey, F., Biancotto, A., Fernandez, M. A., Bettendroffer, L., Blazkova, J., Trejbalova, K., Pion, M., Hirsch, I. (2006). R5 Variants of Human Immunodeficiency Virus Type 1 Preferentially Infect CD62L- CD4+ T Cells and Are Potentially Resistant to Nucleoside Reverse Transcriptase Inhibitors. J. Virol. 80: 854-865 [Abstract] [Full Text]  
• Celli, S., Garcia, Z., Bousso, P. (2005). CD4 T cells integrate signals delivered during successive DC encounters in vivo. JEM 202: 1271-1278 [Abstract] [Full Text]  
• Swain, S. L. (2005). Thanks for the Memory!. J. Immunol. 175: 4823-4826 [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS