The Journal of Experimental Medicine
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Published 4 April 2005. doi:10.1084/jem.20041463
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 7, 1053-1059
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BRIEF DEFINITIVE REPORT

 Interferon-{gamma} acts directly on CD8+ T cells to increase their abundance during virus infection

Jason K. Whitmire1, Joyce T. Tan2, and J. Lindsay Whitton1,2

1 Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037
2 Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037

CORRESPONDENCE J. Lindsay Whitton: lwhitton{at}scripps.edu

Interferon-{gamma} (IFN{gamma}) is important in regulating the adaptive immune response, and most current evidence suggests that it exerts a negative (proapoptotic) effect on CD8+ T cell responses. We have developed a novel technique of dual adoptive transfer, which allowed us to precisely compare, in normal mice, the in vivo antiviral responses of two T cell populations that differ only in their expression of the IFN{gamma} receptor. We use this technique to show that, contrary to expectations, IFN{gamma} strongly stimulates the development of CD8+ T cell responses during an acute viral infection. The stimulatory effect is abrogated in T cells lacking the IFN{gamma} receptor, indicating that the cytokine acts directly upon CD8+ T cells to increase their abundance during acute viral infection.


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