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Christine Borowski and Albert Bendelac

C.B. and A.B. are at the University of Chicago, Chicago, IL 60637.

CORRESPONDENCE A.B.: abendela{at}bsd.uchicago.edu

Abstract
New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing NKT cell development. In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells.

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