The Journal of Experimental Medicine
Torrey Pines Biolabs
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Published 22 February 2005. doi:10.1084/jem.20050197
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 4, 501-504
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COMMENTARY

 Movies, measurement, and modeling : the three Ms of mechanistic immunology



Colleen Witta,b, Subhadip Raychaudhuria,b, and Arup K. Chakrabortya,b

a C.W. and A.K.C. are at University of California, Berkeley, CA 94720.
b S.R. is at University of California, Davis, CA 95616.

CORRESPONDENCE C.W.: cwitt{at}uclink.berkeley.edu OR A.K.C.: arup{at}uclink.berkeley.edu


Abstract
Immunological phenomena that were once deduced from genetic, biochemical, and in situ approaches are now being witnessed in living color, in three dimensions, and in real time. The information in time-lapse imaging can provide valuable mechanistic insight into a host of processes, from cell migration to signal transduction. What we need now are methods to quantitate these new visual data and to exploit computational resources and statistical mechanical methods to develop mechanistic models.


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