Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 809K) PPT slides of all figures Supplemental Material Index Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mora, J. R. Articles by von Andrian, U. H. Search for Related Content PubMed PubMed Citation Articles by Mora, J. R. Articles by von Andrian, U. H. Related Collections Related Article Social Bookmarking                            What's this?

¹ The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115
² Department of Pathology, Harvard Medical School, Boston, MA 02115
³ Millennium Pharmaceuticals, Cambridge, MA 02139

CORRESPONDENCE Ulrich H. von Andrian: uva{at}cbr.med.harvard.edu

T cell activation by intestinal dendritic cells (DC) induces gut-tropism. We show that, reciprocally, DC from peripheral lymph nodes (PLN-DC) induce homing receptors promoting CD8 T cell accumulation in inflamed skin, particularly ligands for P- and E-selectin. Differential imprinting of tissue-tropism was independent of Th1/Th2 cytokines and not restricted to particular DC subsets. Fixed PLN-DC retained the capacity to induce selectin ligands on T cells, which was suppressed by addition of live intestinal DC. By contrast, fixed intestinal DC failed to promote gut-tropism and instead induced skin-homing receptors. Moreover, the induction of selectin ligands driven by antigen-pulsed PLN-DC could be suppressed "in trans" by adding live intestinal DC, but PLN-DC did not suppress gut-homing receptors induced by intestinal DC. Reactivation of tissue-committed memory cells modified their tissue-tropism according to the last activating DC's origin. Thus, CD8 T cells activated by DC acquire selectin ligands by default unless they encounter fixation-sensitive signal(s) for gut-tropism from intestinal DC. Memory T cells remain responsive to these signals, allowing for dynamic migratory reprogramming by skin- and gut-associated DC.

The online version of this article contains supplemental material.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

Related Article

DCs redirect T cell traffic

Heather L. Van Epps
J. Exp. Med. 2005 201: 162. [Full Text] [PDF]

This article has been cited by other articles:

• Carlow, D. A., Gold, M. R., Ziltener, H. J. (2009). Lymphocytes in the Peritoneum Home to the Omentum and Are Activated by Resident Dendritic Cells. J. Immunol. 183: 1155-1165 [Abstract] [Full Text]  
• Bianchi, T., Pincus, L. B., Wurbel, M.-A., Rich, B. E., Kupper, T. S., Fuhlbrigge, R. C., Boes, M. (2009). Maintenance of Peripheral Tolerance through Controlled Tissue Homing of Antigen-Specific T Cells in K14-mOVA Mice. J. Immunol. 182: 4665-4674 [Abstract] [Full Text]  
• Li, N., Chen, Y., He, W., Yi, T., Zhao, D., Zhang, C., Lin, C.-L., Todorov, I., Kandeel, F., Forman, S., Zeng, D. (2009). Anti-CD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI. Blood 113: 953-962 [Abstract] [Full Text]  
• Kim-Schulze, S., Kim, H. S., Wainstein, A., Kim, D. W., Yang, W. C., Moroziewicz, D., Mong, P. Y., Bereta, M., Taback, B., Wang, Q., Kaufman, H. L. (2008). Intrarectal Vaccination with Recombinant Vaccinia Virus Expressing Carcinoembronic Antigen Induces Mucosal and Systemic Immunity and Prevents Progression of Colorectal Cancer. J. Immunol. 181: 8112-8119 [Abstract] [Full Text]  
• Hammerschmidt, S. I., Ahrendt, M., Bode, U., Wahl, B., Kremmer, E., Forster, R., Pabst, O. (2008). Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. JEM 205: 2483-2490 [Abstract] [Full Text]  
• Schepers, K., Swart, E., van Heijst, J. W.J., Gerlach, C., Castrucci, M., Sie, D., Heimerikx, M., Velds, A., Kerkhoven, R. M., Arens, R., Schumacher, T. N.M. (2008). Dissecting T cell lineage relationships by cellular barcoding. JEM 205: 2309-2318 [Abstract] [Full Text]  
• Edele, F., Molenaar, R., Gutle, D., Dudda, J. C., Jakob, T., Homey, B., Mebius, R., Hornef, M., Martin, S. F. (2008). Cutting Edge: Instructive Role of Peripheral Tissue Cells in the Imprinting of T Cell Homing Receptor Patterns. J. Immunol. 181: 3745-3749 [Abstract] [Full Text]  
• Kaufman, D. R., Liu, J., Carville, A., Mansfield, K. G., Havenga, M. J. E., Goudsmit, J., Barouch, D. H. (2008). Trafficking of Antigen-Specific CD8+ T Lymphocytes to Mucosal Surfaces following Intramuscular Vaccination. J. Immunol. 181: 4188-4198 [Abstract] [Full Text]  
• Jaensson, E., Uronen-Hansson, H., Pabst, O., Eksteen, B., Tian, J., Coombes, J. L., Berg, P.-L., Davidsson, T., Powrie, F., Johansson-Lindbom, B., Agace, W. W. (2008). Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. JEM 205: 2139-2149 [Abstract] [Full Text]  
• Elgueta, R., Sepulveda, F. E., Vilches, F., Vargas, L., Mora, J. R., Bono, M. R., Rosemblatt, M. (2008). Imprinting of CCR9 on CD4 T Cells Requires IL-4 Signaling on Mesenteric Lymph Node Dendritic Cells. J. Immunol. 180: 6501-6507 [Abstract] [Full Text]  
• Penitente, R., Nicolo, C., Van den Elzen, P., Di Sante, G., Agrati, C., Aloisi, F., Sercarz, E. E., Ria, F. (2008). Administration of PLP139-151 Primes T Cells Distinct from Those Spontaneously Responsive In Vitro to This Antigen. J. Immunol. 180: 6611-6622 [Abstract] [Full Text]  
• Anderson, B. E., Taylor, P. A., McNiff, J. M., Jain, D., Demetris, A. J., Panoskaltsis-Mortari, A., Ager, A., Blazar, B. R., Shlomchik, W. D., Shlomchik, M. J. (2008). Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 111: 5242-5251 [Abstract] [Full Text]  
• Beilhack, A., Schulz, S., Baker, J., Beilhack, G. F., Nishimura, R., Baker, E. M., Landan, G., Herman, E. I., Butcher, E. C., Contag, C. H., Negrin, R. S. (2008). Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. Blood 111: 2919-2928 [Abstract] [Full Text]  
• Kim, T. D., Terwey, T. H., Zakrzewski, J. L., Suh, D., Kochman, A. A., Chen, M. E., King, C. G., Borsotti, C., Grubin, J., Smith, O. M., Heller, G., Liu, C., Murphy, G. F., Alpdogan, O., van den Brink, M. R. M. (2008). Organ-derived dendritic cells have differential effects on alloreactive T cells. Blood 111: 2929-2940 [Abstract] [Full Text]  
• Gainers, M. E., Descheny, L., Barthel, S. R., Liu, L., Wurbel, M.-A., Dimitroff, C. J. (2007). Skin-Homing Receptors on Effector Leukocytes Are Differentially Sensitive to Glyco-Metabolic Antagonism in Allergic Contact Dermatitis. J. Immunol. 179: 8509-8518 [Abstract] [Full Text]  
• Pals, S. T., de Gorter, D. J. J., Spaargaren, M. (2007). Lymphoma dissemination: the other face of lymphocyte homing. Blood 110: 3102-3111 [Abstract] [Full Text]  
• Saurer, L., McCullough, K. C., Summerfield, A. (2007). In Vitro Induction of Mucosa-Type Dendritic Cells by All-Trans Retinoic Acid. J. Immunol. 179: 3504-3514 [Abstract] [Full Text]  
• Alvarez, D., Arkinson, J. L., Sun, J., Fattouh, R., Walker, T., Jordana, M. (2007). Th2 Differentiation in Distinct Lymph Nodes Influences the Site of Mucosal Th2 Immune-Inflammatory Responses. J. Immunol. 179: 3287-3296 [Abstract] [Full Text]  
• Benson, M. J., Pino-Lagos, K., Rosemblatt, M., Noelle, R. J. (2007). All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. JEM 204: 1765-1774 [Abstract] [Full Text]  
• Masson, F., Calzascia, T., Di Berardino-Besson, W., de Tribolet, N., Dietrich, P.-Y., Walker, P. R. (2007). Brain Microenvironment Promotes the Final Functional Maturation of Tumor-Specific Effector CD8+ T Cells. J. Immunol. 179: 845-853 [Abstract] [Full Text]  
• Chakraverty, R., Sykes, M. (2007). The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Blood 110: 9-17 [Abstract] [Full Text]  
• Jennrich, S., Ratsch, B. A., Hamann, A., Syrbe, U. (2007). Long-Term Commitment to Inflammation-Seeking Homing in CD4+ Effector Cells. J. Immunol. 178: 8073-8080 [Abstract] [Full Text]  
• Ling, K.-L., Dulphy, N., Bahl, P., Salio, M., Maskell, K., Piris, J., Warren, B. F., George, B. D., Mortensen, N. J., Cerundolo, V. (2007). Modulation of CD103 Expression on Human Colon Carcinoma-Specific CTL. J. Immunol. 178: 2908-2915 [Abstract] [Full Text]  
• Marski, M., Ye, A. L., Abraham, C. (2007). CD18 Is Required for Intestinal T Cell Responses at Multiple Immune Checkpoints. J. Immunol. 178: 2104-2112 [Abstract] [Full Text]  
• Sheasley-O'Neill, S. L., Brinkman, C. C., Ferguson, A. R., Dispenza, M. C., Engelhard, V. H. (2007). Dendritic Cell Immunization Route Determines Integrin Expression and Lymphoid and Nonlymphoid Tissue Distribution of CD8 T Cells. J. Immunol. 178: 1512-1522 [Abstract] [Full Text]  
• Hanninen, A., Nurmela, R., Maksimow, M., Heino, J., Jalkanen, S., Kurts, C. (2007). Islet {beta}-Cell-Specific T Cells Can Use Different Homing Mechanisms to Infiltrate and Destroy Pancreatic Islets. Am. J. Pathol. 170: 240-250 [Abstract] [Full Text]  
• Mora, J. R., Iwata, M., Eksteen, B., Song, S.-Y., Junt, T., Senman, B., Otipoby, K. L., Yokota, A., Takeuchi, H., Ricciardi-Castagnoli, P., Rajewsky, K., Adams, D. H., von Andrian, U. H. (2006). Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells.. Science 314: 1157-1160 [Abstract] [Full Text]  
• Klonowski, K. D., Marzo, A. L., Williams, K. J., Lee, S.-J., Pham, Q.-M., Lefrancois, L. (2006). CD8 T Cell Recall Responses Are Regulated by the Tissue Tropism of the Memory Cell and Pathogen. J. Immunol. 177: 6738-6746 [Abstract] [Full Text]  
• Biedermann, T., Lametschwandtner, G., Tangemann, K., Kund, J., Hinteregger, S., Carballido-Perrig, N., Rot, A., Schwarzler, C., Carballido, J. M. (2006). IL-12 Instructs Skin Homing of Human Th2 Cells. J. Immunol. 177: 3763-3770 [Abstract] [Full Text]  
• Chen, J., Fujimoto, C., Vistica, B. P., Wawrousek, E. F., Kelsall, B., Gery, I. (2006). Active participation of antigen-nonspecific lymphoid cells in immune-mediated inflammation.. J. Immunol. 177: 3362-3368 [Abstract] [Full Text]  
• Chakraverty, R., Cote, D., Buchli, J., Cotter, P., Hsu, R., Zhao, G., Sachs, T., Pitsillides, C. M., Bronson, R., Means, T., Lin, C., Sykes, M. (2006). An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues. JEM 203: 2021-2031 [Abstract] [Full Text]  
• Zaph, C., Rook, K. A., Goldschmidt, M., Mohrs, M., Scott, P., Artis, D. (2006). Persistence and Function of Central and Effector Memory CD4+ T Cells following Infection with a Gastrointestinal Helminth. J. Immunol. 177: 511-518 [Abstract] [Full Text]  
• Eksteen, B., Miles, A., Curbishley, S. M., Tselepis, C., Grant, A. J., Walker, L. S. K., Adams, D. H. (2006). Epithelial Inflammation Is Associated with CCL28 Production and the Recruitment of Regulatory T Cells Expressing CCR10. J. Immunol. 177: 593-603 [Abstract] [Full Text]  
• Stenstad, H., Ericsson, A., Johansson-Lindbom, B., Svensson, M., Marsal, J., Mack, M., Picarella, D., Soler, D., Marquez, G., Briskin, M., Agace, W. W. (2006). Gut-associated lymphoid tissue-primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestine. Blood 107: 3447-3454 [Abstract] [Full Text]  
• Trumpfheller, C., Finke, J. S., Lopez, C. B., Moran, T. M., Moltedo, B., Soares, H., Huang, Y., Schlesinger, S. J., Park, C. G., Nussenzweig, M. C., Granelli-Piperno, A., Steinman, R. M. (2006). Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. JEM 203: 607-617 [Abstract] [Full Text]  
• Koelle, D. M., Huang, J., Hensel, M. T., McClurkan, C. L. (2006). Innate Immune Responses to Herpes Simplex Virus Type 2 Influence Skin Homing Molecule Expression by Memory CD4+ Lymphocytes. J. Virol. 80: 2863-2872 [Abstract] [Full Text]  
• Garrood, T., Lee, L., Pitzalis, C. (2006). Molecular mechanisms of cell recruitment to inflammatory sites: general and tissue-specific pathways. Rheumatology (Oxford) 45: 250-260 [Full Text]  
• Alvarez, D., Swirski, F. K., Yang, T.-C., Fattouh, R., Croitoru, K., Bramson, J. L., Stampfli, M. R., Jordana, M. (2006). Inhalation Tolerance Is Induced Selectively in Thoracic Lymph Nodes but Executed Pervasively at Distant Mucosal and Nonmucosal Tissues. J. Immunol. 176: 2568-2580 [Abstract] [Full Text]  
• Annacker, O., Coombes, J. L., Malmstrom, V., Uhlig, H. H., Bourne, T., Johansson-Lindbom, B., Agace, W. W., Parker, C. M., Powrie, F. (2005). Essential role for CD103 in the T cell-mediated regulation of experimental colitis. JEM 202: 1051-1061 [Abstract] [Full Text]  
• Johansson-Lindbom, B., Svensson, M., Pabst, O., Palmqvist, C., Marquez, G., Forster, R., Agace, W. W. (2005). Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. JEM 202: 1063-1073 [Abstract] [Full Text]  
• Beilhack, A., Schulz, S., Baker, J., Beilhack, G. F., Wieland, C. B., Herman, E. I., Baker, E. M., Cao, Y.-A., Contag, C. H., Negrin, R. S. (2005). In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. Blood 106: 1113-1122 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS