Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 3627K) PPT slides of all figures Supplemental Material Index Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lo, C. G. Articles by Cyster, J. G. Search for Related Content PubMed PubMed Citation Articles by Lo, C. G. Articles by Cyster, J. G. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Substance via MeSH Social Bookmarking                      What's this?

¹ Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143
² National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, MD 20892

CORRESPONDENCE Jason G. Cyster: cyster{at}itsa.ucsf.edu

Sphingosine-1-phosphate receptor 1 (S1P₁) was recently shown to be required for lymphocyte egress from lymphoid organs. Here we have examined the relationship between S1P₁ abundance on the cell and egress efficiency. Using an integrin neutralization approach to separate the processes of entry and exit, we show that pertussis toxin treatment reduces lymphocyte egress from lymph nodes. Retrovirally mediated S1P₁ overexpression is sufficient to reduce B cell accumulation in the splenic white pulp and to promote egress of activated T cells from lymph nodes, whereas S1P₁^+/– cells have reduced lymph node exit efficiency. Furthermore, lymphocyte S1P₁ is down-regulated in the blood, up-regulated in lymphoid organs, and down-regulated again in the lymph. We propose that cyclical ligand-induced modulation of S1P₁ on circulating lymphocytes contributes to establishing their lymphoid organ transit time.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Hinman, R. M., Nichols, W. A., Diaz, T. M., Gallardo, T. D., Castrillon, D. H., Satterthwaite, A. B. (2009). Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution. Int Immunol 21: 831-842 [Abstract] [Full Text]  
• Evans, R., Patzak, I., Svensson, L., De Filippo, K., Jones, K., McDowall, A., Hogg, N. (2009). Integrins in immunity. J. Cell Sci. 122: 215-225 [Abstract] [Full Text]  
• Britschgi, M. R., Link, A., Lissandrin, T. K. A., Luther, S. A. (2008). Dynamic Modulation of CCR7 Expression and Function on Naive T Lymphocytes In Vivo. J. Immunol. 181: 7681-7688 [Abstract] [Full Text]  
• Nakasaki, T., Tanaka, T., Okudaira, S., Hirosawa, M., Umemoto, E., Otani, K., Jin, S., Bai, Z., Hayasaka, H., Fukui, Y., Aozasa, K., Fujita, N., Tsuruo, T., Ozono, K., Aoki, J., Miyasaka, M. (2008). Involvement of the Lysophosphatidic Acid-Generating Enzyme Autotaxin in Lymphocyte-Endothelial Cell Interactions. Am. J. Pathol. 173: 1566-1576 [Abstract] [Full Text]  
• Raveney, B. J. E., Copland, D. A., Nicholson, L. B., Dick, A. D. (2008). Fingolimod (FTY720) as an Acute Rescue Therapy for Intraocular Inflammatory Disease. Arch Ophthalmol 126: 1390-1395 [Abstract] [Full Text]  
• Czyzyk, J., Chen, H.-C., Bottomly, K., Flavell, R. A. (2008). p21 Ras/Impedes Mitogenic Signal Propagation Regulates Cytokine Production and Migration in CD4 T Cells. J. Biol. Chem. 283: 23004-23015 [Abstract] [Full Text]  
• Gohda, M., Kunisawa, J., Miura, F., Kagiyama, Y., Kurashima, Y., Higuchi, M., Ishikawa, I., Ogahara, I., Kiyono, H. (2008). Sphingosine 1-Phosphate Regulates the Egress of IgA Plasmablasts from Peyer's Patches for Intestinal IgA Responses. J. Immunol. 180: 5335-5343 [Abstract] [Full Text]  
• Beyer, T., Meyer-Hermann, M. (2008). Mechanisms of organogenesis of primary lymphoid follicles. Int Immunol 20: 615-623 [Abstract] [Full Text]  
• Allende, M. L., Zhou, D., Kalkofen, D. N., Benhamed, S., Tuymetova, G., Borowski, C., Bendelac, A., Proia, R. L. (2008). S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues. FASEB J. 22: 307-315 [Abstract] [Full Text]  
• Foster, C. A., Howard, L. M., Schweitzer, A., Persohn, E., Hiestand, P. C., Balatoni, B., Reuschel, R., Beerli, C., Schwartz, M., Billich, A. (2007). Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis. J. Pharmacol. Exp. Ther. 323: 469-475 [Abstract] [Full Text]  
• Hwang, I.-Y., Park, C., Kehrl, J. H. (2007). Impaired Trafficking of Gnai2+/- and Gnai2-/- T Lymphocytes: Implications for T Cell Movement within Lymph Nodes. J. Immunol. 179: 439-448 [Abstract] [Full Text]  
• Huang, J. H., Cardenas-Navia, L. I., Caldwell, C. C., Plumb, T. J., Radu, C. G., Rocha, P. N., Wilder, T., Bromberg, J. S., Cronstein, B. N., Sitkovsky, M., Dewhirst, M. W., Dustin, M. L. (2007). Requirements for T Lymphocyte Migration in Explanted Lymph Nodes. J. Immunol. 178: 7747-7755 [Abstract] [Full Text]  
• Asperti-Boursin, F., Real, E., Bismuth, G., Trautmann, A., Donnadieu, E. (2007). CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase- independent manner. JEM 204: 1167-1179 [Abstract] [Full Text]  
• Hanel, P., Andreani, P., Graler, M. H. (2007). Erythrocytes store and release sphingosine 1-phosphate in blood. FASEB J. 21: 1202-1209 [Abstract] [Full Text]  
• Nombela-Arrieta, C., Mempel, T. R., Soriano, S. F., Mazo, I., Wymann, M. P., Hirsch, E., Martinez-A., C., Fukui, Y., von Andrian, U. H., Stein, J. V. (2007). A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. JEM 204: 497-510 [Abstract] [Full Text]  
• Maeda, Y., Matsuyuki, H., Shimano, K., Kataoka, H., Sugahara, K., Chiba, K. (2007). Migration of CD4 T Cells and Dendritic Cells toward Sphingosine 1-Phosphate (S1P) Is Mediated by Different Receptor Subtypes: S1P Regulates the Functions of Murine Mature Dendritic Cells via S1P Receptor Type 3. J. Immunol. 178: 3437-3446 [Abstract] [Full Text]  
• Okada, T., Cyster, J. G. (2007). CC Chemokine Receptor 7 Contributes to Gi-Dependent T Cell Motility in the Lymph Node. J. Immunol. 178: 2973-2978 [Abstract] [Full Text]  
• Payne, S. G., Oskeritzian, C. A., Griffiths, R., Subramanian, P., Barbour, S. E., Chalfant, C. E., Milstien, S., Spiegel, S. (2007). The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood 109: 1077-1085 [Abstract] [Full Text]  
• Liao, J.-J., Huang, M.-C., Graler, M., Huang, Y., Qiu, H., Goetzl, E. J. (2007). Distinctive T Cell-suppressive Signals from Nuclearized Type 1 Sphingosine 1-Phosphate G Protein-coupled Receptors. J. Biol. Chem. 282: 1964-1972 [Abstract] [Full Text]  
• Kabashima, K., Haynes, N. M., Xu, Y., Nutt, S. L., Allende, M. L., Proia, R. L., Cyster, J. G. (2006). Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. JEM 203: 2683-2690 [Abstract] [Full Text]  
• Stachowiak, A. N., Wang, Y., Huang, Y.-C., Irvine, D. J. (2006). Homeostatic Lymphoid Chemokines Synergize with Adhesion Ligands to Trigger T and B Lymphocyte Chemokinesis. J. Immunol. 177: 2340-2348 [Abstract] [Full Text]  
• Stenstad, H., Ericsson, A., Johansson-Lindbom, B., Svensson, M., Marsal, J., Mack, M., Picarella, D., Soler, D., Marquez, G., Briskin, M., Agace, W. W. (2006). Gut-associated lymphoid tissue-primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestine. Blood 107: 3447-3454 [Abstract] [Full Text]  
• Pabst, O., Herbrand, H., Willenzon, S., Worbs, T., Schippers, A., Muller, W., Bernhardt, G., Forster, R. (2006). Enhanced FTY720-Mediated Lymphocyte Homing Requires G{alpha}i Signaling and Depends on beta2 and beta7 Integrin. J. Immunol. 176: 1474-1480 [Abstract] [Full Text]  
• Zhang, Q., Chen, Y., Fairchild, R. L., Heeger, P. S., Valujskikh, A. (2006). Lymphoid Sequestration of Alloreactive Memory CD4 T Cells Promotes Cardiac Allograft Survival. J. Immunol. 176: 770-777 [Abstract] [Full Text]  
• Singer, I. I., Tian, M., Wickham, L. A., Lin, J., Matheravidathu, S. S., Forrest, M. J., Mandala, S., Quackenbush, E. J. (2005). Sphingosine-1-Phosphate Agonists Increase Macrophage Homing, Lymphocyte Contacts, and Endothelial Junctional Complex Formation in Murine Lymph Nodes. J. Immunol. 175: 7151-7161 [Abstract] [Full Text]  
• Chalfant, C. E., Spiegel, S. (2005). Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J. Cell Sci. 118: 4605-4612 [Abstract] [Full Text]  
• Hait, N. C., Sarkar, S., Le Stunff, H., Mikami, A., Maceyka, M., Milstien, S., Spiegel, S. (2005). Role of Sphingosine Kinase 2 in Cell Migration toward Epidermal Growth Factor. J. Biol. Chem. 280: 29462-29469 [Abstract] [Full Text]  
• Halin, C., Scimone, M. L., Bonasio, R., Gauguet, J.-M., Mempel, T. R., Quackenbush, E., Proia, R. L., Mandala, S., von Andrian, U. H. (2005). The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. Blood 106: 1314-1322 [Abstract] [Full Text]  
• Lo, C. G., Xu, Y., Proia, R. L., Cyster, J. G. (2005). Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. JCB 168: i5-i5 [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS