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Estelle Bettelli and Vijay K. Kuchroo

CORRESPONDENCE V.K.K.: vkuchroo{at}rics.bwh.harvard.edu

Abstract
Traditionally, CD4⁺ T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23–driven subset of Th cells called Th_IL-17 has now been described. The data suggest that IL-23 plays an important role in the differentiation of autoreactive pathogenic T cells. Whether these IL-23–induced Th_IL-17 cells are a unique subset or are related to other Th subsets is discussed.

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