The Journal of Experimental Medicine
Rockland Immunochemicals for Research
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Published 20 June 2005. doi:10.1084/jem.20050928
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 12, 1881-1884
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COMMENTARY

 Antiviral T cell responses : phalanx or multipronged attack?



David N. Posnetta,b,c, Manuel E. Engelhorna,b,c, and Alan N. Houghtona,b,c

a D.N.P. is at the Department of Medicine, Division of Hematology-Oncology, Weill Medical College, Cornell University, New York, NY 10021.
b M.E.E. and A.N.H. are at Swim Across America Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
c D.N.P., M.E.E., and A.N.H. are at The Immunology Program, Graduate School of Medical Sciences, Weill Medical College, Cornell University, New York, NY 10021.

CORRESPONDENCE D.N.P.: dposnett{at}mail.med.cornell.edu


Abstract
Around 700 BCE, a new military formation called the phalanx was established in ancient Greece: a tight column of heavy infantry carrying long spears, or pikes, used in a single prong of attack. Later, in the battle of Marathon described by Herodotus, the Greeks learned the advantages of multipronged attacks, a strategy still used in modern warfare. Is the immune system similar in its approach to combating pathogens or tumors?


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