The Journal of Experimental Medicine
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Published 20 June 2005. doi:10.1084/jem.20050901
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 12, 1875-1879
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*Asthma
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COMMENTARY

 Nonhuman primate models of asthma

Robert L. Coffman and Edith M. Hessel

R.L.C. and E.M.H. are at Dynavax Technologies, Berkeley, CA 94710.

CORRESPONDENCE R.L.C.: rcoffman{at}dvax.com


Abstract
Asthma is a complex human disease that does not have an accurate counterpart in any common model organism. Most of our understanding of the immune mechanisms underlying asthma comes from studies in man and mouse. However, there are fundamental differences between the spontaneous disease in man and the experimentally induced counterparts in mice. We advocate more extensive use of nonhuman primate asthma models to reconcile these differences between man and mouse.


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