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David G. Bowen^a,b and Christopher M. Walker^a,b

^a D.G.B. and C.M.W. are at Center for Vaccines and Immunity, Columbus Children's Research Institute, Columbus, OH 43205.
^b C.M.W. is at College of Medicine and Public Health, Ohio State University, Columbus, OH 43210.

CORRESPONDENCE C.M.W.: walkerc{at}pediatrics.ohio-state.edu

Abstract
The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I–restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure.

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