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NF-B and the Immunoglobulin Gene Enhancer

Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, MD 21224

Address correspondence to Ranjan Sen, Lab. of Cellular and Molecular Biology, National Institute on Aging, 5600 Nathan Shock Dr., Baltimore, MD 21224. Phone: (410) 558-8630; Fax: (410) 558-8026; email: rs465z{at}nih.gov

Abstract
Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-B has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-B binding site–mutated enhancer in the correct biological context does not appear to affect gene expression.

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