The Journal of Experimental Medicine
Avanti Polar Lipids, Inc.
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published 1 November 2004. doi:10.1084/jem.20041255
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 200, Number 9, 1099-1102
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 481K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sen, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sen, R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Commentary

 NF-{kappa}B and the Immunoglobulin {kappa} Gene Enhancer

Ranjan Sen

Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, MD 21224

Address correspondence to Ranjan Sen, Lab. of Cellular and Molecular Biology, National Institute on Aging, 5600 Nathan Shock Dr., Baltimore, MD 21224. Phone: (410) 558-8630; Fax: (410) 558-8026; email: rs465z{at}nih.gov


Abstract
Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-{kappa}B has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin {kappa} chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-{kappa}B binding site–mutated enhancer in the correct biological context does not appear to affect {kappa} gene expression.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS