The Journal of Experimental Medicine
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Published 1 November 2004. doi:10.1084/jem.20041974
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 200, Number 9, 1093-1097
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Commentary

 Pregnancy-associated Malaria and the Prospects for Syndrome-specific Antimalaria Vaccines

Joseph D. Smith1,2 and Kirk W. Deitsch3

1 Seattle Biomedical Research Institute, Seattle, WA 98109
2 Department of Pathobiology, University of Washington, Seattle, WA 98195
3 Weill Medical College of Cornell University, New York, NY 10021

Address correspondence to Joseph Smith, Seattle Biomedical Research Institute, 307 Westlake Ave. N., Ste. 500, Seattle, WA 98109-5219. Phone: (206) 256-7384; Fax (206) 256-7229; email: joe.smith{at}sbri.org; or Kirk Deitsch, Weill Medical College of Cornell University, 1300 York Ave., Box 62, New York, NY 10021. Phone: (212) 746-4976; Fax: (212) 746-4028; email: kwd2001{at}med.cornell.edu


Abstract
Aided by the Plasmodium falciparum genome project, recent discoveries regarding the molecular basis of malaria pathogenesis have led to a better understanding of the interactions between host and parasite. Although vaccines that prevent infection by malaria parasites remain only hopes for the future, there are now more immediate prospects for vaccines that protect against specific disease syndromes. Here, we discuss the latest advances in the development of a vaccine that specifically targets pregnancy-associated malaria (PAM).


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