The Journal of Experimental Medicine
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Published online 11 October 2004 doi:10.1084/jem.20040779
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 200, Number 8, 1083-1089
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Brief Definitive Report

 CD24 Expression on T Cells Is Required for Optimal T Cell Proliferation in Lymphopenic Host

Ou Li, Pan Zheng, and Yang Liu

Division of Cancer Immunology, Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210

Address correspondence to Yang Liu, Div. of Cancer Immunology, Dept. of Pathology, Ohio State University Medical Center, 129 Hamilton Hall, 1645 Neil Ave., Columbus, OH 43210. Phone: (614) 292-3054; Fax: (614) 688-8152; email: liu-3{at}medctr.osu.edu

It is well established that T lymphocytes undergo homeostatic proliferation in lymphopenic environment. The homeostatic proliferation requires recognition of the major histocompatibility complex on the host. Recent studies have demonstrated that costimulation-mediated CD28, 4-1BB, and CD40 is not required for T cell homeostatic proliferation. It has been suggested that homeostatic proliferation is costimulation independent. Here, we report that T cells from mice with a targeted mutation of CD24 have a remarkably reduced rate of proliferation when adoptively transferred into syngeneic lymphopenic hosts. The reduced proliferation cannot be attributed to abnormal survival and homing properties of the CD24-deficient T cells. T cell proliferation in allogeneic hosts is less affected by this mutation. These results demonstrate a novel function of CD24 expressed on T cells. Thus, although distinct costimulatory molecules are involved in antigen-driven proliferation and homeostatic proliferation, both processes can be modulated by costimulatory molecules.

Key Words: costimulation • homeostasis • autoimmune diseases • immunological memory • T cell traffic


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